AIMC Topic: DNA Methylation
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Assessment of MGMT promoter methylation status in glioblastoma using deep learning features from multi-sequence MRI of intratumoral and peritumoral regions.
Cancer imaging : the official publication of the International Cancer Imaging Society
Dec 23, 2024
OBJECTIVE: This study aims to evaluate the effectiveness of deep learning features derived from multi-sequence magnetic resonance imaging (MRI) in determining the O-methylguanine-DNA methyltransferase (MGMT) promoter methylation status among glioblas...
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis.
The Journal of pathology
Dec 22, 2024
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either through visual pathological review [conv...
Ense-i6mA: Identification of DNA N-Methyladenine Sites Using XGB-RFE Feature Selection and Ensemble Machine Learning.
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
DNA N-methyladenine (6mA) is an important epigenetic modification that plays a vital role in various cellular processes. Accurate identification of the 6mA sites is fundamental to elucidate the biological functions and mechanisms of modification. How...
AI-driven feature selection and epigenetic pattern analysis: A screening strategy of CpGs validated by pyrosequencing for body fluid identification.
Forensic science international
Dec 6, 2024
Identification of body fluid stain at crime scene is one of the important tasks of forensic evidence analysis. Currently, body fluid-specific CpGs detected by DNA methylation microarray screening, have been widely studied for forensic body fluid iden...
EpiBrCan-Lite: A lightweight deep learning model for breast cancer subtype classification using epigenomic data.
Computer methods and programs in biomedicine
Dec 4, 2024
BACKGROUND AND OBJECTIVES: Early breast cancer subtypes classification improves the survival rate as it facilitates prognosis of the patient. In literature this problem was prominently solved by various Machine Learning and Deep Learning techniques. ...
Clinical and Multiomic Features Differentiate Young Black and White Breast Cancer Cohorts Derived by Machine Learning Approaches.
Clinical breast cancer
Nov 28, 2024
BACKGROUND: There are documented differences in Breast cancer (BrCA) presentations and outcomes between Black and White patients. In addition to molecular factors, socioeconomic, racial, and clinical factors result in disparities in outcomes for wome...
Insights to aging prediction with AI based epigenetic clocks.
Epigenomics
Nov 25, 2024
Over the past century, human lifespan has increased remarkably, yet the inevitability of aging persists. The disparity between biological age, which reflects pathological deterioration and disease, and chronological age, indicative of normal aging, h...
Graph Convolutional Network for AD and MCI Diagnosis Utilizing Peripheral DNA Methylation: Réseau de neurones en graphes pour le diagnostic de la MA et du TCL à l'aide de la méthylation de l'ADN périphérique.
Canadian journal of psychiatry. Revue canadienne de psychiatrie
Nov 25, 2024
OBJECTIVE: Blood DNA methylation (DNAm) alterations have been widely reported in the onset and progression of mild cognitive impairment (MCI) and Alzheimer's disease (AD); however, DNAm is underutilized as a diagnostic biomarker for these diseases. W...
Robust double machine learning model with application to omics data.
BMC bioinformatics
Nov 14, 2024
BACKGROUND: Recently, there has been a growing interest in combining causal inference with machine learning algorithms. Double machine learning model (DML), as an implementation of this combination, has received widespread attention for their experti...
AI tool for predicting MGMT methylation in glioblastoma for clinical decision support in resource limited settings.
Scientific reports
Nov 14, 2024
Glioblastoma is an aggressive brain cancer with a poor prognosis. The O6-methylguanine-DNA methyltransferase (MGMT) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to devel...
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