AIMC Topic: DNA

Clear Filters Showing 241 to 250 of 457 articles

A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation.

Biochimica et biophysica acta. Molecular basis of disease Aug 7, 2020
Carcinoma of unknown primary (CUP), defined as metastatic cancers with unknown cancer origin, occurs in 3-5 per 100 cancer patients in the United States. Heterogeneity and metastasis of cancer brings great difficulties to the follow-up diagnosis and ...
Machine Learning Algorithms Mutation Positron-Emission Tomography Neoplasms, Unknown Primary Sequence Analysis, DNA DNA
View on PubMed DOI

Predicting gene regulatory regions with a convolutional neural network for processing double-strand genome sequence information.

PloS one Jul 23, 2020
With advances in sequencing technology, a vast amount of genomic sequence information has become available. However, annotating biological functions particularly of non-protein-coding regions in genome sequences without experiments is still a challen...
Regulatory Sequences, Nucleic Acid Mice Genomics DNA Software Genome Humans Sequence Analysis, DNA Animals Neural Networks, Computer
View on PubMed DOI

Robotic DNA Nanostructures.

ACS synthetic biology Jul 12, 2020
Over the past decade, DNA nanotechnology has spawned a broad variety of functional nanostructures tailored toward the enabled state at which applications are coming increasingly in view. One of the branches of these applications is in synthetic biolo...
Nanomedicine Nanostructures Biosensing Techniques Nanotechnology Robotics Drug Carriers DNA
View on PubMed DOI

A secured cryptographic system based on DNA and a hybrid key generation approach.

Bio Systems Jul 9, 2020
Cryptography is a method for preventing illegitimate access to information and data. In this paper, a bio-inspired cryptographic DNA system has been proposed. The proposed method consists of three phases: encryption, key generation and decryption. Th...
Computer Security Algorithms Computer Simulation DNA Neural Networks, Computer
View on PubMed DOI

Synthesis Success Calculator: Predicting the Rapid Synthesis of DNA Fragments with Machine Learning.

ACS synthetic biology Jun 30, 2020
The synthesis and assembly of long DNA fragments has greatly accelerated synthetic biology and biotechnology research. However, long turnaround times or synthesis failures create unpredictable bottlenecks in the design-build-test-learn cycle. We deve...
DNA Fragmentation Plasmids Genome, Bacterial Nucleic Acid Conformation Databases, Genetic DNA Software Escherichia coli Machine Learning
View on PubMed DOI

Denoising DNA Encoded Library Screens with Sparse Learning.

ACS combinatorial science Jun 26, 2020
DNA-encoded libraries (DELs) are large, pooled collections of compounds in which every library member is attached to a stretch of DNA encoding its complete synthetic history. DEL-based hit discovery involves affinity selection of the library against ...
DNA Gene Library Machine Learning
View on PubMed DOI

A Generative Neural Network for Maximizing Fitness and Diversity of Synthetic DNA and Protein Sequences.

Cell systems Jun 25, 2020
Engineering gene and protein sequences with defined functional properties is a major goal of synthetic biology. Deep neural network models, together with gradient ascent-style optimization, show promise for sequence design. The generated sequences ca...
Sequence Analysis, Protein Neural Networks, Computer DNA Humans
View on PubMed DOI

Hereditary disease prediction in eukaryotic DNA: an adaptive signal processing approach.

Nucleosides, nucleotides & nucleic acids Jun 22, 2020
Hereditary disease prediction in eukaryotic DNA using signal processing approaches is an incredible work in bioinformatics. Researchers of various fields are trying to put forth a noninvasive approach to forecast the disease-related genes. As disease...
Neural Networks, Computer Algorithms Computational Biology Humans Eukaryota Genetic Diseases, Inborn DNA Mutation
View on PubMed DOI

Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis.

Journal of visualized experiments : JoVE Jun 18, 2020
Glomerular cell death is a pathological feature of myeloperoxidase anti neutrophil cytoplasmic antibody associated vasculitis (MPO-AAV). Extracellular deoxyribonucleic acid (ecDNA) is released during different forms of cell death including apoptosis,...
Animals Male Extracellular Traps Mice, Inbred C57BL Image Processing, Computer-Assisted Humans Supervised Machine Learning Peroxidase Extracellular Space Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Glomerulonephritis DNA Kidney Glomerulus Biopsy Models, Biological
View on PubMed DOI

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.

Journal of medicinal chemistry Jun 11, 2020
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecul...
Neural Networks, Computer Drug Discovery DNA Small Molecule Libraries Proto-Oncogene Proteins c-kit Estrogen Receptor alpha Ligands Protein Kinase Inhibitors Epoxide Hydrolases
View on PubMed DOI
Popular Topics
Recent Journals