AIMC Topic: Dogs

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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

European journal of medicinal chemistry Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Haplorhini Cell Line Pyrroles Protein-Tyrosine Kinases Humans Cell Proliferation Structure-Activity Relationship Animals Rats, Sprague-Dawley Microsomes, Liver Arthritis, Rheumatoid Dose-Response Relationship, Drug Protein Kinase Inhibitors Rats Models, Molecular Pyrimidines Drug Design Molecular Structure Agammaglobulinaemia Tyrosine Kinase Mice Dogs
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Anti-pandemic influenza A (H1N1) virus potential of catechin and gallic acid.

Journal of the Chinese Medical Association : JCMA Dec 26, 2017
BACKGROUND: The pandemic influenza A (H1N1) virus has spread worldwide and infected a large proportion of the human population. Discovery of new and effective drugs for the treatment of influenza is a crucial issue for the global medical community. A...
Gallic Acid Dogs Madin Darby Canine Kidney Cells Virus Replication Animals Humans Antiviral Agents A549 Cells Catechin Influenza A Virus, H1N1 Subtype
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Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Dec 21, 2017
PURPOSE: Lifitegrast is approved in the United States for the treatment of dry eye disease (DED). We assessed lifitegrast's ocular distribution/pharmacokinetic profile in rabbits, and C-lifitegrast mass balance/excretion in dogs.
Phenylalanine Ophthalmic Solutions Administration, Topical Dogs Dry Eye Syndromes Rabbits Cornea Female Animals Sulfones
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Can Dogs Assist Children with Severe Autism Spectrum Disorder in Complying with Challenging Demands? An Exploratory Experiment with a Live and a Robotic Dog.

Journal of alternative and complementary medicine (New York, N.Y.) Nov 8, 2017
OBJECTIVES: Prompted by the need to find effective ways to enhance compliance in children with autism spectrum disorder (ASD), and building on the increasing interest in dog-assisted interventions for this population, this study provides an explorato...
Male Child Emotions Autism Spectrum Disorder Female Animals Task Performance and Analysis Patient Preference Animal Assisted Therapy Robotics Child Behavior Humans Dogs Heart Rate
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A rapid and sensitive supercritical fluid chromatography/tandem mass spectrometry method for detection of ezetimibein dog plasma and its application in pharmacokinetic studies.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Oct 28, 2017
The aim of this study is to develop and validate a rapid, high-selective and sensitive supercritical fluid chromatography/tandem mass spectrometry (SFC-MS/MS) with a multiple reactions monitoring (MRM) mode method for the detection of ezetimibe in do...
Chromatography, Supercritical Fluid Ezetimibe Tandem Mass Spectrometry Animals Drug Stability Reproducibility of Results Linear Models Sensitivity and Specificity Dogs
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A sonographic investigation for the development of ultrasound-guided paravertebral brachial plexus block in dogs: cadaveric study.

Veterinary anaesthesia and analgesia Sep 15, 2017
OBJECTIVE: To describe a novel in-plane ultrasound (US)-guided approach to the sixth (C6), seventh (C7), eighth (C8) cervical and to the first thoracic (T1) spinal nerves.
Brachial Plexus Block Feasibility Studies Dogs Cadaver Prospective Studies Animals Ultrasonography, Interventional
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A Functional-Genetic Scheme for Seizure Forecasting in Canine Epilepsy.

IEEE transactions on bio-medical engineering Sep 13, 2017
OBJECTIVE: The objective of this work is the development of an accurate seizure forecasting algorithm that considers brain's functional connectivity for electrode selection.
Support Vector Machine Cluster Analysis Epilepsy Electrocorticography Signal Processing, Computer-Assisted Dogs Animals
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Unsupervised Myocardial Segmentation for Cardiac BOLD.

IEEE transactions on medical imaging Jul 12, 2017
A fully automated 2-D+time myocardial segmentation framework is proposed for cardiac magnetic resonance (CMR) blood-oxygen-level-dependent (BOLD) data sets. Ischemia detection with CINE BOLD CMR relies on spatio-temporal patterns in myocardial intens...
Algorithms Animals Dogs Magnetic Resonance Imaging, Cine Image Processing, Computer-Assisted Unsupervised Machine Learning Heart
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Prediction of lymph node parasite load from clinical data in dogs with leishmaniasis: An application of radial basis artificial neural networks.

Veterinary parasitology Dec 22, 2016
Quantification of Leishmania infantum load via real-time quantitative polymerase chain reaction (qPCR) in lymph node aspirates is an accurate tool for diagnostics, surveillance and therapeutics follow-up in dogs with leishmaniasis. However, qPCR requ...
Neural Networks, Computer Animals Leishmaniasis Parasite Load Lymph Nodes Dogs Dog Diseases
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Development of a plasminogen activator inhibitor (PAI-1) assay and comparison of plasma PAI-1 activity in hyperlipidemic/dyslipidemic dogs with either hyperadrenocorticism or diabetes mellitus, and healthy dogs.

Research in veterinary science Nov 8, 2016
Thrombosis is a serious complication of many canine diseases and may be related to decreased fibrinolytic potential. Plasminogen activator inhibitor-1 (PAI-1) is the key regulator of fibrinolysis with increased levels demonstrated in states of pro-th...
Adrenocortical Hyperfunction Plasminogen Activator Inhibitor 1 Hyperlipidemias Serologic Tests Female Sensitivity and Specificity Animals Dogs Dog Diseases Male Diabetes Mellitus Humans
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