UNLABELLED: PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface supporting data...
BACKGROUND: Neuroimaging studies have yielded significant advances in the understanding of neural processes relevant to the development and persistence of addiction. However, these advances have not explored extensively for diagnostic accuracy in hum...
Progress in neuro-psychopharmacology & biological psychiatry
31352033
There is a growing need to address the variability in detecting cognitive deficits with standard tests in cocaine dependence (CD). The aim of the current study was to identify cognitive deficits by means of Machine Learning (ML) algorithms: Generaliz...
The United States of America is fighting against one of its worst-ever drug crises. Over 900 people a week die from opioid- or heroin-related overdoses, while millions more suffer from opioid prescription addiction. Recently, drug overdoses caused by...
Existing work on drug-induced synaptic changes has shown that the expression of perineuronal nets (PNNs) at the cerebellar cortex can be regulated by cocaine-related memory. However, these studies on animals have mostly relied on limited manually-dri...
The journal of physical chemistry letters
34752088
No anti-cocaine addiction drugs have been approved by the Food and Drug Administration despite decades of effort. The main challenge is the intricate molecular mechanisms of cocaine addiction, involving synergistic interactions among proteins upstrea...
BACKGROUND: The sophisticated behavioral and cognitive repertoires of non-human primates (NHPs) make them suitable subjects for studies involving cocaine self-administration (SA) schedules. However, ethical considerations, adherence to the 3Rs princi...
PURPOSE: Cocaine is one of the most commonly used drugs that may lead to physical and mental health problems. It is necessary to identify individuals having cocaine use disorder as early as possible to monitor them properly. The objective of this wor...