AIMC Topic: Drug Carriers
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CochleRob: Parallel-Serial Robot to Position a Magnetic Actuator around a Patient's Head for Intracochlear Microrobot Navigation.
Sensors (Basel, Switzerland)
Mar 9, 2023
Our work introduces a new robotic solution named CochleRob, which is used for the administration of super-paramagnetic antiparticles as drug carriers into the human cochlea for the treatment of hearing loss caused by damaged cochlea. This novel robot...
Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach.
Drug development and industrial pharmacy
May 19, 2022
OBJECTIVE: The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for effective o...
Magnetic Biohybrid Robots as Efficient Drug Carrier to Generate Plant Cell Clones.
Small (Weinheim an der Bergstrasse, Germany)
May 10, 2022
Micro/nanorobots represent a new generation of micromachines that can accomplish various tasks, such as loading and transporting specific targets or pharmaceuticals for a given application. Biohybrid robots consisting of biological cells (bacteria, s...
Formulation and optimization of silymarin-encapsulated binary micelles for enhanced amyloid disaggregation activity.
Drug development and industrial pharmacy
Apr 9, 2022
Silymarin (SLY) is a natural hydrophobic polyphenol that possesses antioxidant and amyloid fibril (Aβ) inhibition activity, but its activity is hindered due to low aqueous solubility. In this study, SLY is encapsulated in binary micelle (SLY-BM) that...
Magnetic Biohybrid Microrobot Multimers Based on Cells for Enhanced Targeted Drug Delivery.
ACS applied materials & interfaces
Jan 12, 2022
Magnetic micro-/nanorobots have been regarded as a promising platform for targeted drug delivery, and tremendous strategies have been developed in recent years. However, realizing precise and efficient drug delivery in vivo still remains challenging,...
Prediction of Anti-Glioblastoma Drug-Decorated Nanoparticle Delivery Systems Using Molecular Descriptors and Machine Learning.
International journal of molecular sciences
Oct 26, 2021
The theoretical prediction of drug-decorated nanoparticles (DDNPs) has become a very important task in medical applications. For the current paper, Perturbation Theory Machine Learning (PTML) models were built to predict the probability of different ...
Biodegradable Small-Scale Swimmers for Biomedical Applications.
Advanced materials (Deerfield Beach, Fla.)
Sep 3, 2021
Most forms of biomatter are ephemeral, which means they transform or deteriorate after a certain time. From this perspective, implantable healthcare devices designed for temporary treatments should exhibit the ability to degrade and either blend in w...
Design of novel orotransmucosal vaccine-delivery platforms using artificial intelligence.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Dec 28, 2020
The linings of the oral cavity are excellent needle-free vaccination sites, able to induce immune responses at distal sites and confer systemic protection. However, owing to the mucosal tissues' intrinsic characteristics, the design of effective anti...
Engineering microrobots for targeted cancer therapies from a medical perspective.
Nature communications
Nov 5, 2020
Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of ...
Robotic DNA Nanostructures.
ACS synthetic biology
Jul 12, 2020
Over the past decade, DNA nanotechnology has spawned a broad variety of functional nanostructures tailored toward the enabled state at which applications are coming increasingly in view. One of the branches of these applications is in synthetic biolo...
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