AIMC Topic: Drug Delivery Systems

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Prioritizing Pain-Associated Targets with Machine Learning.

Biochemistry Feb 19, 2021
While hundreds of genes have been associated with pain, much of the molecular mechanisms of pain remain unknown. As a result, current analgesics are limited to few clinically validated targets. Here, we trained a machine learning (ML) ensemble model ...
Pain Drug Delivery Systems Drug Design Analgesics Models, Biological Drug Discovery Humans Machine Learning
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Efficient Prediction of In Vitro Piroxicam Release and Diffusion From Topical Films Based on Biopolymers Using Deep Learning Models and Generative Adversarial Networks.

Journal of pharmaceutical sciences Feb 3, 2021
The purpose of this study was to simultaneously predict the drug release and skin permeation of Piroxicam (PX) topical films based on Chitosan (CTS), Xanthan gum (XG) and its Carboxymethyl derivatives (CMXs) as matrix systems. These films were prepar...
Deep Learning Chitosan Administration, Cutaneous Drug Delivery Systems Piroxicam
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Smart Materials for Microrobots.

Chemical reviews Feb 1, 2021
Over the past 15 years, the field of microrobotics has exploded with many research groups from around the globe contributing to numerous innovations that have led to exciting new capabilities and important applications, ranging from drug delivery, t...
Drug Delivery Systems Humans Robotics Smart Materials
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Multi-functionalized micro-helical capsule robots with superior loading and releasing capabilities.

Journal of materials chemistry. B Jan 20, 2021
The functionalization of microrobots is essential for realizing their biomedical application in targeted cargo delivery, but the multifunctional integration of microrobots and controllable cargo delivery remains an enormous challenge at present. This...
Drug Liberation Drug Delivery Systems Robotics Humans
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Fighting viruses with materials science: Prospects for antivirus surfaces, drug delivery systems and artificial intelligence.

Dental materials : official publication of the Academy of Dental Materials Jan 10, 2021
OBJECTIVE: Viruses on environmental surfaces, in saliva and other body fluids represent risk of contamination for general population and healthcare professionals. The development of vaccines and medicines is costly and time consuming. Thus, the devel...
Artificial Intelligence COVID-19 Antiviral Agents Materials Science Drug Delivery Systems Humans
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Magnetically actuated intelligent hydrogel-based child-parent microrobots for targeted drug delivery.

Journal of materials chemistry. B Jan 5, 2021
Small intestine-targeted drug delivery by oral administration has aroused the growing interest of researchers. In this work, the child-parent microrobot (CPM) as a vehicle protects the child microrobots (CMs) under a gastric acid environment and rele...
Drug Delivery Systems Child Particle Size Humans Cells, Cultured Magnetic Phenomena Doxorubicin Hydrogels Robotics Magnetite Nanoparticles Surface Properties Lab-On-A-Chip Devices
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Assessing Drug Development Risk Using Big Data and Machine Learning.

Cancer research Dec 22, 2020
Identifying new drug targets and developing safe and effective drugs is both challenging and risky. Furthermore, characterizing drug development risk, the probability that a drug will eventually receive regulatory approval, has been notoriously hard ...
Antineoplastic Agents Machine Learning Big Data Patient Safety Drug-Related Side Effects and Adverse Reactions Humans Male Female Drug Development Risk Assessment Drug Delivery Systems Neoplasms
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Trends in Micro-/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications.

Advanced materials (Deerfield Beach, Fla.) Dec 4, 2020
Micro-/nanorobots (m-bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, their applications in in vivo diagnosis and intervention have been the foc...
Robotics Nanotechnology Animals Wound Healing Humans Drug Delivery Systems
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Engineering microrobots for targeted cancer therapies from a medical perspective.

Nature communications Nov 5, 2020
Systemic chemotherapy remains the backbone of many cancer treatments. Due to its untargeted nature and the severe side effects it can cause, numerous nanomedicine approaches have been developed to overcome these issues. However, targeted delivery of ...
Humans Drug Delivery Systems Robotics Nanomedicine Neoplasms Interdisciplinary Communication Drug Carriers
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Spatiotemporal identification of druggable binding sites using deep learning.

Communications biology Oct 27, 2020
Identification of novel protein binding sites expands druggable genome and opens new opportunities for drug discovery. Generally, presence or absence of a binding site depends on the three-dimensional conformation of a protein, making binding site id...
Receptors, Purinergic P2X3 Receptors, G-Protein-Coupled Deep Learning Binding Sites Models, Molecular Adenosine Triphosphate Protein Binding Ion Channel Gating Software Models, Biological Protein Conformation Drug Delivery Systems
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