AIMC Topic: Drug Liberation
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Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells.
Scientific reports
Apr 12, 2021
Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delive...
Predicting drug release from diazepam FDM printed tablets using deep learning approach: Influence of process parameters and tablet surface/volume ratio.
International journal of pharmaceutics
Mar 23, 2021
The aim of this study was to apply artificial neural networks as deep learning tools in establishing a model for understanding and prediction of diazepam release from fused deposition modeling (FDM) printed tablets. Diazepam printed tablets of variou...
Multi-functionalized micro-helical capsule robots with superior loading and releasing capabilities.
Journal of materials chemistry. B
Jan 20, 2021
The functionalization of microrobots is essential for realizing their biomedical application in targeted cargo delivery, but the multifunctional integration of microrobots and controllable cargo delivery remains an enormous challenge at present. This...
Design of novel orotransmucosal vaccine-delivery platforms using artificial intelligence.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Dec 28, 2020
The linings of the oral cavity are excellent needle-free vaccination sites, able to induce immune responses at distal sites and confer systemic protection. However, owing to the mucosal tissues' intrinsic characteristics, the design of effective anti...
An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Dec 7, 2020
Drugs in solid dispersion (SD) take advantage of fast and extended dissolution, thus attains a higher bioavailability than the crystal form. However, current development of SD relies on a random large-scale formulation screening method with low effic...
M3DISEEN: A novel machine learning approach for predicting the 3D printability of medicines.
International journal of pharmaceutics
Sep 20, 2020
Artificial intelligence (AI) has the potential to reshape pharmaceutical formulation development through its ability to analyze and continuously monitor large datasets. Fused deposition modeling (FDM) three-dimensional printing (3DP) has made signifi...
Delineating the effects of hot-melt extrusion on the performance of a polymeric film using artificial neural networks and an evolutionary algorithm.
International journal of pharmaceutics
Sep 24, 2019
The aim of this study was to utilize an artificial neural network (ANN) in conjunction with an evolutionary algorithm to investigate the relationship between hot melt extrusion (HME) process parameters and vaginal film performance. Investigated HME p...
Application of artificial neural networks for Process Analytical Technology-based dissolution testing.
International journal of pharmaceutics
Jun 25, 2019
This work proposes the application of artificial neural networks (ANN) to non-destructively predict the in vitro dissolution of pharmaceutical tablets from Process Analytical Technology (PAT) data. An extended release tablet formulation was studied, ...
Investigation of magnetic silica with thermoresponsive chitosan coating for drug controlled release and magnetic hyperthermia application.
Materials science & engineering. C, Materials for biological applications
Nov 30, 2018
In this study, a drug delivery system for chemo-hyperthermia applications is proposed and fabricated. The delivery system consists of magnetic-silica (MagSi) particles being encapsulated within a pH/thermo-responsive chitosan‑g‑N‑isopropylacrylamide ...
Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.
Biomedical microdevices
Nov 16, 2018
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradabil...
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