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Drug Liberation

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Preparation of agar nanospheres: comparison of response surface and artificial neural network modeling by a genetic algorithm approach.

Carbohydrate polymers
Multivariate nature of drug loaded nanospheres manufacturing in term of multiplicity of involved factors makes it a time consuming and expensive process. In this study genetic algorithm (GA) and artificial neural network (ANN), two tools inspired by ...

Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine.

Technology in cancer research & treatment
OBJECTIVE: This study presents a comparative analysis of RF and SVM for predicting calcein release from ultrasound-triggered, targeted liposomes under varied low-frequency ultrasound (LFUS) power densities (6.2, 9, and 10 mW/cm).

Diversified Applications of Self-assembled Nanocluster Delivery Systems- A State-ofthe- art Review.

Current pharmaceutical design
BACKGROUND: For the nanoparticulate system and the transportation of cellular elements for the fabrication of microelectronic devices, self-assembled nanoclusters arrange the components into an organized structure. Nanoclusters reduce transcytosis an...

Optimization of metronidazole SR buccal tablet for gingivitis using genetic algorithm.

Pakistan journal of pharmaceutical sciences
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal table...

Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.

Pakistan journal of pharmaceutical sciences
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...

Prediction of Dissolution Data Integrated in Tablet Database Using Four-Layered Artificial Neural Networks.

Chemical & pharmaceutical bulletin
A large number of dissolution data were measured and integrated into a previously constructed tablet database composed of 14 kinds of compounds as model active pharmaceutical ingredients (APIs) with contents ranging from 10 to 80%. The database has c...

Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogel...