AIMC Topic: Drug Liberation

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Preparation of agar nanospheres: comparison of response surface and artificial neural network modeling by a genetic algorithm approach.

Carbohydrate polymers Dec 31, 2014
Multivariate nature of drug loaded nanospheres manufacturing in term of multiplicity of involved factors makes it a time consuming and expensive process. In this study genetic algorithm (GA) and artificial neural network (ANN), two tools inspired by ...
Drug Liberation Neural Networks, Computer Agar Surface Properties Algorithms Bupropion Nanospheres
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Implementing partial least squares and machine learning regressive models for prediction of drug release in targeted drug delivery application.

Scientific reports Jul 2, 2025
A combined methodology was performed based on chemometrics and machine learning regressive models in estimation of polysaccharide-coated colonic drug delivery. The release of medication was measured using Raman spectroscopy and the data was used for ...
Spectrum Analysis, Raman Least-Squares Analysis Machine Learning Drug Liberation Drug Delivery Systems
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Machine learning predictions of drug release from isocyanate-derived aerogels.

Journal of materials chemistry. B May 28, 2025
This work utilized machine learning (ML) algorithms to predict and validate the drug release kinetics of a short worm-like nanostructured isocyanate-derived aerogel: the first time ML has been employed to study the drug delivery properties of this i...
Machine Learning Particle Size Porosity Kinetics Isocyanates Nanostructures Drug Liberation Gels
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Supervised machine learning for predicting drug release from acetalated dextran nanofibers.

Biomaterials science May 13, 2025
Electrospun drug-loaded polymeric nanofibers can improve the efficacy of therapeutics for a variety of implications. By design, these biomaterial platforms can enhance drug bioavailability and site-specific delivery while reducing off-target toxiciti...
Machine Learning Drug Carriers Supervised Machine Learning Drug Liberation Dextrans Nanofibers
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A novel scheme for non-invasive drug delivery with a magnetically controlled drug delivering capsule endoscope.

Journal of controlled release : official journal of the Controlled Release Society May 10, 2025
There is a lack of effective means for precise drug delivery of gastrointestinal diseases. Herein we report a novel magnetically controlled drug delivering capsule endoscope (MDCE) to achieve precision drug delivery for gastrointestinal diseases. MDC...
Norepinephrine Drug Liberation Capsule Endoscopy Drug Delivery Systems Animals Swine Capsule Endoscopes
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Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine.

Technology in cancer research & treatment Jan 1, 2024
OBJECTIVE: This study presents a comparative analysis of RF and SVM for predicting calcein release from ultrasound-triggered, targeted liposomes under varied low-frequency ultrasound (LFUS) power densities (6.2, 9, and 10 mW/cm).
Humans Drug Delivery Systems Support Vector Machine Liposomes Ultrasonic Waves Fluoresceins Random Forest Drug Liberation
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Diversified Applications of Self-assembled Nanocluster Delivery Systems- A State-ofthe- art Review.

Current pharmaceutical design Jan 1, 2022
BACKGROUND: For the nanoparticulate system and the transportation of cellular elements for the fabrication of microelectronic devices, self-assembled nanoclusters arrange the components into an organized structure. Nanoclusters reduce transcytosis an...
Humans Artificial Intelligence Peptides Polymers Nanostructures Drug Liberation
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Optimization of metronidazole SR buccal tablet for gingivitis using genetic algorithm.

Pakistan journal of pharmaceutical sciences Nov 1, 2021
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal table...
Adhesiveness Administration, Buccal Tablets Diffusion Drug Liberation Drug Compounding Artificial Intelligence Delayed-Action Preparations Kinetics Anti-Bacterial Agents Metronidazole Gingivitis Polymers Hydrogen-Ion Concentration
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Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Although ebastine (EBT) can impede histamine-induced skin allergic reaction and persuade long acting selective H1 receptor antagonistic effects but its poor water solubility circumscribed its clinical application. The main objective of this research ...
Biological Availability Solubility Phosphatidylcholines Butyrophenones Nanoparticles Piperidines Drug Liberation Drug Compounding Bile Acids and Salts Administration, Oral Liposomes Histamine H1 Antagonists
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DEVELOPMENT AND VALIDATION OF HPLC ANALYTICAL METHODS USED-FOR DETERMINATION OF ASSAY, CONTENT UNIFORMITY AND DISSOLUTION OF IMMEDIATE RELEASE CANDESARTAN CILEXETIL 32 MG TABLETS.

Acta poloniae pharmaceutica Mar 1, 2017
New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies wer...
Benzimidazoles Angiotensin II Type 1 Receptor Blockers Buffers Chemistry, Pharmaceutical Tetrazoles Reproducibility of Results Drug Compounding Limit of Detection Linear Models Drug Liberation Hydrogen-Ion Concentration Tablets Temperature Biphenyl Compounds Chromatography, High Pressure Liquid Solvents Solubility
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