AIMC Topic: Drug Liberation
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Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Aug 5, 2015
The acceleration of solid dosage form product development can be facilitated by the inclusion of excipients that exhibit poly-/multi-functionality with reduction of the time invested in multiple excipient optimisations. Because active pharmaceutical ...
Algorithms
Compressive Strength
Porosity
Indomethacin
Tablets
Computational Biology
Anti-Inflammatory Agents, Non-Steroidal
Drug Compounding
Drug Liberation
Surface Properties
Mechanical Phenomena
Arginine
Powders
Elasticity
Excipients
Microscopy, Electron, Scanning
Expert Systems
Static Electricity
Tensile Strength
Statistics as Topic
Preparation of agar nanospheres: comparison of response surface and artificial neural network modeling by a genetic algorithm approach.
Carbohydrate polymers
Dec 31, 2014
Multivariate nature of drug loaded nanospheres manufacturing in term of multiplicity of involved factors makes it a time consuming and expensive process. In this study genetic algorithm (GA) and artificial neural network (ANN), two tools inspired by ...
Advancing Amorphous Solid Dispersions Design: Insights into Dissolution Kinetics via Thermodynamic Descriptor and Machine Learning.
Molecular pharmaceutics
Jul 7, 2025
Amorphous solid dispersions (ASD) are an effective strategy for enhancing the solubility and bioavailability of poorly soluble drugs. However, designing and optimizing ASD formulations often rely on extensive dissolution experiments without sufficie...
Machine learning predictions of drug release from isocyanate-derived aerogels.
Journal of materials chemistry. B
May 28, 2025
This work utilized machine learning (ML) algorithms to predict and validate the drug release kinetics of a short worm-like nanostructured isocyanate-derived aerogel: the first time ML has been employed to study the drug delivery properties of this i...
Supervised machine learning for predicting drug release from acetalated dextran nanofibers.
Biomaterials science
May 13, 2025
Electrospun drug-loaded polymeric nanofibers can improve the efficacy of therapeutics for a variety of implications. By design, these biomaterial platforms can enhance drug bioavailability and site-specific delivery while reducing off-target toxiciti...
A novel scheme for non-invasive drug delivery with a magnetically controlled drug delivering capsule endoscope.
Journal of controlled release : official journal of the Controlled Release Society
May 10, 2025
There is a lack of effective means for precise drug delivery of gastrointestinal diseases. Herein we report a novel magnetically controlled drug delivering capsule endoscope (MDCE) to achieve precision drug delivery for gastrointestinal diseases. MDC...
Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine.
Technology in cancer research & treatment
Jan 1, 2024
OBJECTIVE: This study presents a comparative analysis of RF and SVM for predicting calcein release from ultrasound-triggered, targeted liposomes under varied low-frequency ultrasound (LFUS) power densities (6.2, 9, and 10 mW/cm).
Diversified Applications of Self-assembled Nanocluster Delivery Systems- A State-ofthe- art Review.
Current pharmaceutical design
Jan 1, 2022
BACKGROUND: For the nanoparticulate system and the transportation of cellular elements for the fabrication of microelectronic devices, self-assembled nanoclusters arrange the components into an organized structure. Nanoclusters reduce transcytosis an...
Optimization of metronidazole SR buccal tablet for gingivitis using genetic algorithm.
Pakistan journal of pharmaceutical sciences
Nov 1, 2021
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal table...
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