AIMC Topic: Poloxamer

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Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.

Pharmaceutical development and technology Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
Humans Cell Line, Tumor Cell Survival Lipids Drug Carriers Anti-Inflammatory Agents, Non-Steroidal Ophthalmic Solutions Nanostructures Drug Liberation Rheology Drug Stability Drug Compounding Surface Properties Viscosity Delayed-Action Preparations Ibuprofen Lubricant Eye Drops Poloxamer
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Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.

Drug development and industrial pharmacy Jun 11, 2015
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...
Neural Networks, Computer Research Design Polyethylene Glycols Chemistry, Pharmaceutical Polyvinyls Poloxamer
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Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Neural Networks, Computer Algorithms Computer Simulation Nanoparticles Particle Size Lipids Drug Carriers Models, Chemical Polymers Kinetics Verapamil Solubility Nanomedicine Technology, Pharmaceutical Surface Properties Calcium Channel Blockers Chemistry, Pharmaceutical Delayed-Action Preparations Poloxamer Polysorbates
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