AIMC Topic: Poloxamer

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Pluronic nanoparticle-modified modular bacterial robots for therapy of tumors and inflammatory bowel disease.

Journal of materials chemistry. B Dec 10, 2025
Bacterial-mediated drug delivery has emerged as a promising strategy for disease treatment, leveraging bacteria's innate ability to penetrate biological barriers and target diseased tissues. However, existing bacteria-nanoparticle hybrid systems ofte...
Mice Nanoparticles Animals Antineoplastic Agents Micelles Humans Surface Properties Inflammatory Bowel Diseases Poloxamer Particle Size Breast Neoplasms Robotics Drug Delivery Systems Female
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Predictive modeling approach using machine learning-integrated design of experiments in quality by design for optimizing resveratrol-loaded polymeric nanoparticle formulation.

International journal of pharmaceutics Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
Nanoparticles Antioxidants Machine Learning Animals Polymers Drug Compounding Administration, Cutaneous Particle Size Drug Carriers Skin Absorption Resveratrol Chemistry, Pharmaceutical Poloxamer
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Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.

Pharmaceutical development and technology Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
Poloxamer Drug Stability Drug Compounding Drug Carriers Drug Liberation Anti-Inflammatory Agents, Non-Steroidal Ophthalmic Solutions Rheology Cell Survival Delayed-Action Preparations Surface Properties Nanostructures Humans Ibuprofen Lipids Viscosity Lubricant Eye Drops Cell Line, Tumor
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Combined application of mixture experimental design and artificial neural networks in the solid dispersion development.

Drug development and industrial pharmacy Jun 11, 2015
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus®-poloxamer 188 SDs were prepared by solven...
Research Design Polyethylene Glycols Polyvinyls Poloxamer Chemistry, Pharmaceutical Neural Networks, Computer
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Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Polysorbates Delayed-Action Preparations Poloxamer Nanoparticles Particle Size Nanomedicine Drug Carriers Technology, Pharmaceutical Models, Chemical Verapamil Calcium Channel Blockers Lipids Solubility Chemistry, Pharmaceutical Surface Properties Polymers Algorithms Neural Networks, Computer Kinetics Computer Simulation
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