AIMC Topic: Electron Microscope Tomography
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Volumetric macromolecule identification in cryo-electron tomograms using capsule networks.
BMC bioinformatics
Aug 30, 2022
BACKGROUND: Despite recent advances in cellular cryo-electron tomography (CET), developing automated tools for macromolecule identification in submolecular resolution remains challenging due to the lack of annotated data and high structural complexit...
MemBrain: A deep learning-aided pipeline for detection of membrane proteins in Cryo-electron tomograms.
Computer methods and programs in biomedicine
Jul 1, 2022
BACKGROUND AND OBJECTIVE: Cryo-electron tomography (cryo-ET) is an imaging technique that enables 3D visualization of the native cellular environment at sub-nanometer resolution, providing unpreceded insights into the molecular organization of cells....
Low-Dose Sparse-View HAADF-STEM-EDX Tomography of Nanocrystals Using Unsupervised Deep Learning.
ACS nano
Jun 21, 2022
High-angle annular dark-field (HAADF) scanning transmission electron microscopy (STEM) can be acquired together with energy dispersive X-ray (EDX) spectroscopy to give complementary information on the nanoparticles being imaged. Recent deep learning ...
Macromolecules Structural Classification With a 3D Dilated Dense Network in Cryo-Electron Tomography.
IEEE/ACM transactions on computational biology and bioinformatics
Feb 3, 2022
Cryo-electron tomography, combined with subtomogram averaging (STA), can reveal three-dimensional (3D) macromolecule structures in the near-native state from cells and other biological samples. In STA, to get a high-resolution 3D view of macromolecul...
Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning.
Nature cell biology
Dec 7, 2021
Simultaneous imaging of various facets of intact biological systems across multiple spatiotemporal scales is a long-standing goal in biology and medicine, for which progress is hindered by limits of conventional imaging modalities. Here we propose us...
Subcellular Fractions
Electron Microscope Tomography
COS Cells
Lipid Droplets
Optical Imaging
Refractometry
Cell Nucleolus
Actins
Cell Membrane
Humans
Animals
Mitochondria
3T3 Cells
Deep Learning
Chlorocebus aethiops
HEK293 Cells
Single-Cell Analysis
Cell Line, Tumor
HeLa Cells
Imaging, Three-Dimensional
Cell Nucleus
Mice
Deep learning improves macromolecule identification in 3D cellular cryo-electron tomograms.
Nature methods
Oct 21, 2021
Cryogenic electron tomography (cryo-ET) visualizes the 3D spatial distribution of macromolecules at nanometer resolution inside native cells. However, automated identification of macromolecules inside cellular tomograms is challenged by noise and rec...
Automatic localization and identification of mitochondria in cellular electron cryo-tomography using faster-RCNN.
BMC bioinformatics
Mar 29, 2019
BACKGROUND: Cryo-electron tomography (cryo-ET) enables the 3D visualization of cellular organization in near-native state which plays important roles in the field of structural cell biology. However, due to the low signal-to-noise ratio (SNR), large ...
Convolutional neural networks for automated annotation of cellular cryo-electron tomograms.
Nature methods
Aug 28, 2017
Cellular electron cryotomography offers researchers the ability to observe macromolecules frozen in action in situ, but a primary challenge with this technique is identifying molecular components within the crowded cellular environment. We introduce ...
AITom: AI-guided cryo-electron tomography image analyses toolkit.
Journal of structural biology
Jun 1, 2025
Cryo-electron tomography (cryo-ET) is an essential tool in structural biology, uniquely capable of visualizing three-dimensional macromolecular complexes within their native cellular environments, thereby providing profound molecular-level insights. ...
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography.
Proceedings of the National Academy of Sciences of the United States of America
May 13, 2025
Phase separation is an important mechanism to generate certain biomolecular condensates and organize the cell interior. Condensate formation and function remain incompletely understood due to difficulties in visualizing the condensate interior at hig...
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