AIMC Topic: Excipients

Clear Filters Showing 41 to 50 of 50 articles

An accurate and precise representation of drug ingredients.

Journal of biomedical semantics Apr 19, 2016
BACKGROUND: In previous work, we built the Drug Ontology (DrOn) to support comparative effectiveness research use cases. Here, we have updated our representation of ingredients to include both active ingredients (and their strengths) and excipients. ...
Cytochrome P-450 Enzyme Inhibitors Isoenzymes Pharmaceutical Preparations Cytochrome P-450 Enzyme System Biological Ontologies Excipients
View on PubMed DOI

Risk assessment of supply chain for pharmaceutical excipients with AHP-fuzzy comprehensive evaluation.

Drug development and industrial pharmacy Aug 12, 2015
As the essential components in formulations, pharmaceutical excipients directly affect the safety, efficacy, and stability of drugs. Recently, safety incidents of pharmaceutical excipients posing seriously threats to the patients highlight the necess...
Drug Evaluation, Preclinical Drug Industry Excipients Polysorbates Risk Assessment Fuzzy Logic
View on PubMed DOI

A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Aug 5, 2015
The acceleration of solid dosage form product development can be facilitated by the inclusion of excipients that exhibit poly-/multi-functionality with reduction of the time invested in multiple excipient optimisations. Because active pharmaceutical ...
Microscopy, Electron, Scanning Excipients Compressive Strength Surface Properties Indomethacin Elasticity Algorithms Computational Biology Static Electricity Anti-Inflammatory Agents, Non-Steroidal Tensile Strength Statistics as Topic Mechanical Phenomena Porosity Powders Tablets Expert Systems Drug Liberation Drug Compounding Arginine
View on PubMed DOI

Comparison of novel granulated pellet-containing tablets and traditional pellet-containing tablets by artificial neural networks.

Pharmaceutical development and technology Apr 24, 2014
Novel granulated pellets technique was adopted to prepare granulated pellet-containing tablets (GPCT). GPCT and traditional pellet-containing tablets (PCT) were prepared according to 29 formulations devised by the Design Expert 7.0, with doxycycline ...
Doxycycline Polymethacrylic Acids Drug Compounding Excipients Hardness Particle Size Neural Networks, Computer Models, Chemical Anti-Bacterial Agents Tablets Solubility
View on PubMed DOI

Enhancing YOLOv8n with Mamba-like linear attention for defect detection and coating thickness analysis of irregular film tablet.

International journal of pharmaceutics Jun 10, 2025
This study presents a real-time system that integrates deep learning and machine vision for defect detection and coating thickness measurement of irregularly shaped film-coated tablets. To overcome the accuracy and speed limitations of the traditiona...
Technology, Pharmaceutical Chemistry, Pharmaceutical Excipients Tablets, Enteric-Coated Deep Learning Image Processing, Computer-Assisted Tablets Drug Compounding
View on PubMed DOI

Deep learning-based image classification and quantification models for tablet sticking.

International journal of pharmaceutics Jun 10, 2025
Sticking can significantly affect drug product quality, manufacturing efficiency, and therapeutic efficacy in pharmaceutical tablet manufacturing. This study presents a novel integrated model with a convolutional neural network (CNN) and gray-level c...
Tablets Drug Compounding Technology, Pharmaceutical Excipients Neural Networks, Computer Deep Learning Support Vector Machine
View on PubMed DOI

Artificial Intelligence Technologies used for the Assessment of Pharmaceutical Excipients.

Current pharmaceutical design Jan 1, 2024
Humans Artificial Intelligence Pharmaceutical Preparations Excipients
View on PubMed DOI

Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Humans Machine Learning United States Hep G2 Cells Mice, Inbred BALB C Pharmaceutical Preparations Female Animals Swine Abietanes Excipients Retinyl Esters United States Food and Drug Administration Food Diterpenes Glucuronosyltransferase ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Interactions Biological Assay
View on PubMed DOI

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets.

Acta pharmaceutica (Zagreb, Croatia) Jun 27, 2017
Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeD...
Excipients Hardness Expert Systems Drug Compounding Ibuprofen Humans Tablets Administration, Oral Solubility Pediatrics
View on PubMed DOI

Long-term Stability of Esomeprazole in 5% Dextrose Infusion Polyolefin Bags at 5 degrees C +/- 3 degrees C after Microwave Freeze-thaw Treatment.

International journal of pharmaceutical compounding Jan 1, 2015
To improve quality assurance, security, time management, and cost saving of drug delivery, preparation in advance of intravenous solutions has been developed for several infusion solutions. The objective of this study was to investigate the stability...
Esomeprazole Spectrophotometry, Ultraviolet Dosage Forms Excipients Freezing Chemistry, Pharmaceutical Proton Pump Inhibitors Glucose Asepsis Time Factors Drug Compounding Hydrogen-Ion Concentration Infusions, Intravenous Chromatography, High Pressure Liquid Technology, Pharmaceutical Equipment Design Drug Stability Microwaves Cold Temperature Drug Packaging Polyenes Chromatography, Reverse-Phase
View on PubMed
Popular Topics
Recent Journals