AIMC Topic: Fentanyl

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Comparison of ropivacaine with and without fentanyl vs bupivacaine with fentanyl for postoperative epidural analgesia in bilateral total knee replacement surgery.

Journal of clinical anesthesia Dec 22, 2016
STUDY OBJECTIVES: Pain after total knee replacement (TKR) interferes with early rehabilitation. Although the use of epidural bupivacaine in post-TKR patients is associated with effective analgesia, the associated motor blockade effect delays function...
Humans Prospective Studies Female Aged Male Middle Aged Treatment Outcome Drug Combinations Amides Postoperative Care Anesthetics, Local Pain Measurement Double-Blind Method Pain, Postoperative Bupivacaine Ropivacaine Analgesics, Opioid Fentanyl Osteoarthritis Analgesia, Patient-Controlled Arthroplasty, Replacement, Knee Pain Management Patient Satisfaction Nausea Analgesia, Epidural
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Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression.

Function (Oxford, England) May 19, 2025
Previous studies reported that opioids depress breathing by inhibiting respiratory neural networks in the brainstem. The effects of opioids on sensory inputs regulating breathing are less studied. This study examined the effects of fentanyl and sufen...
Animals Male Rats Rats, Sprague-Dawley Analgesics, Opioid Fentanyl Respiratory Insufficiency Carotid Body Receptors, Opioid, kappa
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Predicting the structure of unexplored novel fentanyl analogues by deep learning model.

Briefings in bioinformatics Nov 19, 2022
Fentanyl and its analogues are psychoactive substances and the concern of fentanyl abuse has been existed in decades. Because the structure of fentanyl is easy to be modified, criminals may synthesize new fentanyl analogues to avoid supervision. The ...
Deep Learning Data Management Analgesics, Opioid Fentanyl Magnetic Resonance Spectroscopy
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[Rapid screening and determination of fentanyl and its analogues in drugs by liquid chromatography- quadrupole time-of-flight mass spectrometry].

Se pu = Chinese journal of chromatography Aug 8, 2020
A method based on liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) was developed for the simultaneous screening and determination of fentanyl and its 26 analogs in liquid and solid powder dru...
Pharmaceutical Preparations Fentanyl Chromatography, High Pressure Liquid Tandem Mass Spectrometry Solid Phase Extraction
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