BACKGROUND: Methotrexate (MTX) in the body can result in severe, potentially life-threatening side effects. As a result, it is imperative to establish a dependable, precise, and specific method for detecting MTX. However, conventional sensors often s...
As crucial biomarkers of food spoilage, portable and real-time monitoring of the biogenic amines (BAs) is essential to ensuring food safety. In light of this, a ratiometric fluorescent probe (Tb@HOF-BPTC) is developed, which exhibits distinct fluores...
Journal of the American Chemical Society
Jul 2, 2025
Fluorescence lifetime imaging microscopy (FLIM) is a powerful optical tool widely used in biomedical research to study changes in a sample's microenvironment. However, data collection and interpretation are often challenging, and traditional methods ...
Developing analytical methods for simultaneous detection of multiple antibiotic residues is crucial for environmental protection and human health. In this study, a dual lanthanide fluorescence probe (GDP-Eu-Tb) based on nucleotides has been designed....
Synthetic cannabinoids, a novel class of highly toxic psychoactive substances with various disguised forms, have posed significant risks to public safety, and their weak reactivity presents a substantial challenge for swift and accurate analysis. In ...
Fluorescence lifetime imaging microscopy (FLIM) has been widely used as an essential multiplexing and sensing tool in frontier fields such as materials science and life sciences. However, the accuracy of lifetime estimation is compromised by limited ...
Proteins can be rapidly prototyped with cell-free expression (CFE) but in most cases there is a lack of probes or assays to measure their function directly in the cell lysate, thereby limiting the throughput of these screens. Increased throughput is ...
As metabolic byproducts and representative indicators of food spoilage, the monitoring and detection for biogenic amines (BAs) are crucial but challenging for food quality assessment. Here, a strategy is proposed by combining fluorescent probe molecu...
Extracellular vesicles (EVs) are promising non-invasive biomarkers for cancer diagnosis. EVs proteins play a critical role in tumor progress and metastasis. However, accurately and reliably diagnosing cancers is greatly limited by single protein mark...
The accuracy of assigning fluorophore identity and abundance, known as spectral unmixing, in biological fluorescence microscopy images remains a significant challenge due to the substantial overlap in emission spectra among fluorophores. In tradition...
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