AIMC Topic: Freezing
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Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction.
Molecular pharmaceutics
Jun 19, 2020
There has been much recent interest in machine learning (ML) and molecular quantitative structure property relationships (QSPR). The present research evaluated modern ML-based methods implemented in commercial software (COSMOquick and Molecular Model...
Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times.
eLife
Jun 10, 2020
Dopamine (DA) neurons are to encode reward prediction error (RPE), in addition to other signals, such as salience. While RPE is known to support learning, the role of salience in learning remains less clear. To address this, we recorded and manipulat...
Combined molecular dynamics and neural network method for predicting protein antifreeze activity.
Proceedings of the National Academy of Sciences of the United States of America
Dec 7, 2018
Antifreeze proteins (AFPs) are a diverse class of proteins that depress the kinetically observable freezing point of water. AFPs have been of scientific interest for decades, but the lack of an accurate model for predicting AFP activity has hindered ...
Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations.
Journal of pharmaceutical sciences
Oct 27, 2018
Current technologies for monitoring the subvisible particles that may be generated during fill-finish operations for protein formulations are cumbersome. Measurement times are generally too long for real-time analysis, and the high protein concentrat...
Effect of Using Two Cryopreservation Methods on Viability and Fertility of Frozen Stallion Sperm.
Journal of equine veterinary science
Oct 24, 2018
Studies involving different methods and techniques of cryopreservation and its interactions with the conception rates in artificial insemination (AI) programs are reported in the literature. This study evaluated the sperm kinetics, plasma membrane in...
The application of convolution neural network based cell segmentation during cryopreservation.
Cryobiology
Sep 13, 2018
For most of the cells, water permeability and plasma membrane properties play a vital role in the optimal protocol for successful cryopreservation. Measuring the water permeability of cells during subzero temperature is essential. So far, there is no...
Improved freeze drying efficiency by ice nucleation proteins with ice morphology modification.
Food research international (Ottawa, Ont.)
Dec 14, 2017
This study aims to use ice nucleation proteins (INPs) as a novel approach to improve the efficiency of freeze drying process and investigate the related mechanism of ice morphology. Our results show that INPs can significantly improve freeze drying e...
Sperm quality and its freezing ability throughout the spawning season in Prochilodus lineatus and Brycon orbignyanus.
Theriogenology
Dec 18, 2016
The aim of this study was to determine fresh and frozen sperm quality evaluated over two spawning seasons (2013-2014; 2014-2015) in Prochilodus lineatus and Brycon orbignyanus. The spawning seasons were divided into two sampling periods: November to ...
Predicting Melting Points of Organic Molecules: Applications to Aqueous Solubility Prediction Using the General Solubility Equation.
Molecular informatics
Jul 20, 2015
In this work we make predictions of several important molecular properties of academic and industrial importance to seek answers to two questions: 1) Can we apply efficient machine learning techniques, using inexpensive descriptors, to predict meltin...
Corn Seed Freezing Damage Identification of Different Sides Based on Hyperspectral Imaging and SPA-2DCOS Fusion Algorithm.
Molecules (Basel, Switzerland)
May 15, 2025
In order to improve the utilization efficiency of corn seeds and meet the demand of single-seed seeding technology in agriculture, this study was conducted to explore the effect of freezing damage detection on the endosperm and embryo sides of single...
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