AIMC Topic: Freezing
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Cryo-Electron Microscopic Grid Preparation for Time-Resolved Studies using a Novel Robotic System, Spotiton.
Journal of visualized experiments : JoVE
Feb 25, 2021
The capture of short-lived molecular states triggered by the early encounter of two or more interacting particles continues to be an experimental challenge of great interest to the field of cryo-electron microscopy (cryo-EM). A few methodological str...
Cryostructuring of Polymeric Systems : Application of Deep Neural Networks for the Classification of Structural Features Peculiar to Macroporous Poly(vinyl alcohol) Cryogels Prepared without and with the Additives of Chaotropes or Kosmotropes.
Molecules (Basel, Switzerland)
Sep 29, 2020
Macroporous poly(vinyl alcohol) cryogels (PVACGs) are physical gels formed via cryogenic processing of polymer solutions. The properties of PVACGs depend on many factors: the characteristics and concentration of PVA, the absence or presence of foreig...
Machine Estimation of Drug Melting Properties and Influence on Solubility Prediction.
Molecular pharmaceutics
Jun 19, 2020
There has been much recent interest in machine learning (ML) and molecular quantitative structure property relationships (QSPR). The present research evaluated modern ML-based methods implemented in commercial software (COSMOquick and Molecular Model...
Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times.
eLife
Jun 10, 2020
Dopamine (DA) neurons are to encode reward prediction error (RPE), in addition to other signals, such as salience. While RPE is known to support learning, the role of salience in learning remains less clear. To address this, we recorded and manipulat...
Combined molecular dynamics and neural network method for predicting protein antifreeze activity.
Proceedings of the National Academy of Sciences of the United States of America
Dec 7, 2018
Antifreeze proteins (AFPs) are a diverse class of proteins that depress the kinetically observable freezing point of water. AFPs have been of scientific interest for decades, but the lack of an accurate model for predicting AFP activity has hindered ...
Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations.
Journal of pharmaceutical sciences
Oct 27, 2018
Current technologies for monitoring the subvisible particles that may be generated during fill-finish operations for protein formulations are cumbersome. Measurement times are generally too long for real-time analysis, and the high protein concentrat...
Effect of Using Two Cryopreservation Methods on Viability and Fertility of Frozen Stallion Sperm.
Journal of equine veterinary science
Oct 24, 2018
Studies involving different methods and techniques of cryopreservation and its interactions with the conception rates in artificial insemination (AI) programs are reported in the literature. This study evaluated the sperm kinetics, plasma membrane in...
The application of convolution neural network based cell segmentation during cryopreservation.
Cryobiology
Sep 13, 2018
For most of the cells, water permeability and plasma membrane properties play a vital role in the optimal protocol for successful cryopreservation. Measuring the water permeability of cells during subzero temperature is essential. So far, there is no...
Improved freeze drying efficiency by ice nucleation proteins with ice morphology modification.
Food research international (Ottawa, Ont.)
Dec 14, 2017
This study aims to use ice nucleation proteins (INPs) as a novel approach to improve the efficiency of freeze drying process and investigate the related mechanism of ice morphology. Our results show that INPs can significantly improve freeze drying e...
Sperm quality and its freezing ability throughout the spawning season in Prochilodus lineatus and Brycon orbignyanus.
Theriogenology
Dec 18, 2016
The aim of this study was to determine fresh and frozen sperm quality evaluated over two spawning seasons (2013-2014; 2014-2015) in Prochilodus lineatus and Brycon orbignyanus. The spawning seasons were divided into two sampling periods: November to ...
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