Machine learning and deep learning are extensively employed in genomic selection (GS) to expedite the identification of superior genotypes and accelerate breeding cycles. However, a significant challenge with current data-driven deep learning models ...
Ovarian cancer is a malignant tumor with different clinicopathological and molecular characteristics. Due to its nonspecific early symptoms, the majority of patients are diagnosed with local or extensive metastasis, severely affecting treatment and p...
The rapid evolution of artificial intelligence (AI) is redefining biomedicine, placing itself at the forefront of groundbreaking discoveries in molecular biology, genomics, drug discovery, diagnostics, and beyond [...].
BACKGROUND AND OBJECTIVE: Timely treatment is crucial for cancer patients, so it's important to administer the appropriate treatment as soon as possible. Because individuals can respond differently to a given drug due to their unique genomic profiles...
The Plant journal : for cell and molecular biology
Dec 12, 2024
Due to its excellent performance in processing large amounts of data and capturing complex non-linear relationships, deep learning has been widely applied in many fields of plant biology. Here we first review the application of deep learning in analy...
BACKGROUND/OBJECTIVES: Understanding the relationship between DNA sequences and gene expression levels is of significant biological importance. Recent advancements have demonstrated the ability of deep learning to predict gene expression levels direc...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
In this paper, we propose a Learning-based gEnome Codec (LEC), which is designed for high efficiency and enhanced flexibility. The LEC integrates several advanced technologies, including Group of Bases (GoB) compression, multi-stride coding and bidir...
Accurately predicting druggable genes is of paramount importance for enhancing the efficacy of targeted therapies, reducing drug-related toxicities and improving patients' survival rates. Nevertheless, accurately predicting candidate cancer-druggable...
AD is a progressive neurodegenerative disorder characterized by memory loss. Due to the advancement in next-generation sequencing, an enormous amount of AD-associated genomics data is available. However, the information about the involvement of these...
International journal of biological macromolecules
Dec 4, 2024
Although recent advancements have shed light on the crucial role of coordinated evolution among cell subpopulations in influencing disease progression, the full potential of these insights has not yet been fully harnessed in the clinical application ...
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