AIMC Topic: HIV-1

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Robotic selection for the rapid development of stable CHO cell lines for HIV vaccine production.

PloS one Aug 2, 2018
The production of envelope glycoproteins (Envs) for use as HIV vaccines is challenging. The yield of Envs expressed in stable Chinese Hamster Ovary (CHO) cell lines is typically 10-100 fold lower than other glycoproteins of pharmaceutical interest. M...
HIV Antibodies HEK293 Cells Antibody Formation Cricetinae AIDS Vaccines Humans Automation, Laboratory Robotics Animals Antibodies, Neutralizing CHO Cells HIV-1 Cricetulus High-Throughput Screening Assays
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A Machine Learning Approach for Predicting HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds.

Journal of chemical information and modeling Jul 17, 2018
HIV resistance emerging against antiretroviral drugs represents a great threat to the continued prolongation of the lifespans of HIV-infected patients. Therefore, methods capable of predicting resistance susceptibility in the development of compounds...
Humans Machine Learning Drug Discovery Reverse Transcriptase Inhibitors Drug Resistance, Viral HIV Reverse Transcriptase Point Mutation HIV Infections Bayes Theorem Models, Biological HIV-1
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Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.

Journal of neurovirology Dec 19, 2017
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Interleukin-18 HIV-1 Interleukin-6 Docosahexaenoic Acids Disease Models, Animal Corpus Striatum Animals Locomotion Gene Expression Endotoxins Maze Learning Male NF-kappa B Binge Drinking HIV Infections Rats, Transgenic Rats, Inbred F344 Rats
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What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM.

EBioMedicine Dec 7, 2017
BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background.
Male Humans Homosexuality, Male Phylogeny Adult Sexual Partners HIV Infections T-Lymphocytes Genetic Background HIV-1
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Improving fold resistance prediction of HIV-1 against protease and reverse transcriptase inhibitors using artificial neural networks.

BMC bioinformatics Aug 15, 2017
BACKGROUND: Drug resistance in HIV treatment is still a worldwide problem. Predicting resistance to antiretrovirals (ARVs) before starting any treatment is important. Prediction accuracy is essential, as low-accuracy predictions increase the risk of ...
Humans Neural Networks, Computer Databases, Factual HIV Infections HIV Protease HIV-1 HIV Protease Inhibitors Reverse Transcriptase Inhibitors HIV Reverse Transcriptase Drug Resistance, Viral
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A machine learning approach for viral genome classification.

BMC bioinformatics Apr 11, 2017
BACKGROUND: Advances in cloning and sequencing technology are yielding a massive number of viral genomes. The classification and annotation of these genomes constitute important assets in the discovery of genomic variability, taxonomic characteristic...
Hepatitis B virus Genomics Sequence Analysis, RNA Sequence Analysis, DNA Humans Machine Learning Computer Simulation HIV-1 Genome, Viral Classification Papillomaviridae
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Prediction of HIV-1 protease cleavage site using a combination of sequence, structural, and physicochemical features.

BMC bioinformatics Dec 23, 2016
BACKGROUND: The human immunodeficiency virus type 1 (HIV-1) aspartic protease is an important enzyme owing to its imperative part in viral development and a causative agent of deadliest disease known as acquired immune deficiency syndrome (AIDS). Dev...
HIV Protease Protein Conformation Substrate Specificity Decision Trees Amino Acid Sequence HIV-1 Data Accuracy Humans Algorithms Neural Networks, Computer HIV Infections Computational Biology
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Learning the Relationship between the Primary Structure of HIV Envelope Glycoproteins and Neutralization Activity of Particular Antibodies by Using Artificial Neural Networks.

International journal of molecular sciences Oct 11, 2016
The dependency between the primary structure of HIV envelope glycoproteins (ENV) and the neutralization data for given antibodies is very complicated and depends on a large number of factors, such as the binding affinity of a given antibody for a giv...
Databases, Protein Models, Molecular Antibodies, Neutralizing HIV-1 Inhibitory Concentration 50 Crystallography, X-Ray Magnetic Resonance Spectroscopy HIV Envelope Protein gp120 Humans Neural Networks, Computer HIV Infections
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Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy.

Anais da Academia Brasileira de Ciencias Mar 4, 2016
The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug ...
Virus Replication Antiretroviral Therapy, Highly Active HIV-1 Drug Resistance, Viral Humans Neural Networks, Computer Mutation
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Efavirenz pharmacogenetics in a cohort of Italian patients.

International journal of antimicrobial agents Dec 18, 2015
The pharmacogenetics and pharmacokinetics of efavirenz (EFV) have been widely studied, although data in the Italian population are limited. Single nucleotide polymorphisms (SNPs) in the CYP2B6 gene have been associated with increased EFV plasma conce...
Humans Retrospective Studies Female Adult Male Polymerase Chain Reaction Polymorphism, Single Nucleotide Plasma Cyclopropanes Constitutive Androstane Receptor Middle Aged Italy Benzoxazines Alkynes Pharmacogenetics HIV-1 Anti-HIV Agents
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