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Probing light chain mutation effects on thrombin via molecular dynamics simulations and machine learning.

Journal of biomolecular structure & dynamics
Thrombin is a key component for chemotherapeutic and antithrombotic therapy development. As the physiologic and pathologic roles of the light chain still remain vague, here, we continue previous efforts to understand the impacts of the disease-associ...

A machine learning approach to detect changes in gait parameters following a fatiguing occupational task.

Ergonomics
The purpose of this study is to provide a method for classifying non-fatigued vs. fatigued states following manual material handling. A method of template matching pattern recognition for feature extraction ($1 Recognizer) along with the support vect...

Using Big Data Analytics to Advance Precision Radiation Oncology.

International journal of radiation oncology, biology, physics
Big clinical data analytics as a primary component of precision medicine is discussed, identifying where these emerging tools fit in the spectrum of genomics and radiomics research. A learning health system (LHS) is conceptualized that uses clinicall...

Motor-commands decoding using peripheral nerve signals: a review.

Journal of neural engineering
During the last few decades, substantial scientific and technological efforts have been focused on the development of neuroprostheses. The major emphasis has been on techniques for connecting the human nervous system with a robotic prosthesis via nat...

Use the force: deformation correction in robotic 3D ultrasound.

International journal of computer assisted radiology and surgery
PURPOSE: Ultrasound acquisitions are typically affected by deformations due to the pressure applied onto the contact surface. While a certain amount of pressure is necessary to ensure good acoustic coupling and visibility of the anatomy under examina...

Initial Design and Experimental Evaluation of a Pneumatic Interference Actuator.

Soft robotics
Substantial device mass and control complexity can hinder the impact of wearable robotic technologies, such as exoskeletons. Thus, despite promising previous research, the development of a simple, lightweight actuator for these systems has not yet be...

Grey Language Hesitant Fuzzy Group Decision Making Method Based on Kernel and Grey Scale.

International journal of environmental research and public health
Based on grey language multi-attribute group decision making, a kernel and grey scale scoring function is put forward according to the definition of grey language and the meaning of the kernel and grey scale. The function introduces grey scale into t...