Biological tissues exhibit complex gene expression and multicellular patterns that are valuable to dissect. Single-cell RNA sequencing (scRNA-seq) provides full coverages of genes, but lacks spatial information, whereas spatial transcriptomics (ST) m...
The design of proteins capable effectively binding to specific protein targets is crucial for developing therapies, diagnostics, and vaccine candidates for viral infections. Here, we introduce a complementarity-determining region (CDR) grafting appro...
The Journal of international medical research
Apr 21, 2025
ObjectiveCompared with anatomical magnetic resonance imaging modalities, metabolite images from magnetic resonance spectroscopic imaging often suffer from low quality and detail due to their larger voxel sizes. Conventional interpolation techniques a...
Hypertension is a multifaceted cardiovascular disease, a significant risk factor for stroke, heart attack, heart failure, and renal damage. An essential phase in the drug development process is the exploration of effective bioanalytical approaches to...
OBJECTIVE: This study aims to investigate the ability of ChatGPT to generate reliably accurate responses to patient-based queries specifically regarding oropharyngeal squamous cell carcinoma (OPSCC) of the head and neck.
Artificial Intelligence (AI) is revolutionizing rehabilitation by enabling data-driven, personalized, and effective patient care. AI systems analyze patterns, predict outcomes, and adapt treatments to individual needs, empowering clinicians to delive...
Accurate assessment of training status in team sports is crucial for optimising performance and reducing injury risk. This pilot study investigates the feasibility of using machine learning (ML) models to estimate oxygen uptake (VO2) with wearable se...
American journal of Alzheimer's disease and other dementias
Apr 21, 2025
A growing body of literature has examined the impact of neighborhood characteristics on Alzheimer's disease (AD) dementia, yet the spatial variability and relative importance of the most influential factors remain underexplored. We compiled various w...
Science & justice : journal of the Forensic Science Society
Apr 20, 2025
Forensic casework and crime scene examination will often involve the identification and analysis of biological evidence found on a wide variety of surfaces. One type of biological evidence most commonly encountered at the crime scene is body fluids, ...
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Apr 20, 2025
BACKGROUND: Readmissions following deep inferior epigastric perforator (DIEP) flap breast reconstruction represent a significant healthcare burden, yet current risk prediction methods lack precision in identifying high-risk patients. We developed a m...
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