AIMC Topic: Hypertension

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Candesartan Mitigates Perioperative Neurocognitive Disorders by Modulating Hypertension-Linked Neuroinflammatory Factor.

Neurochemical research
Perioperative neurocognitive disorders (PND) are linked to neuroinflammation, a key factor in hypertension, but their causal relationship is underexplored. This study aims to investigate whether hypertension is a risk factor for PND, identify related...

Identifying patterns of high intraoperative blood pressure variability in noncardiac surgery using explainable machine learning: a retrospective cohort study.

Annals of medicine
BACKGROUND: High intraoperative blood pressure variability (HIBPV) is significantly associated with postoperative adverse complications. However, practical tools to characterize perioperative factors associated with HIBPV remain limited. This study a...

Clinical characteristics and CKD care delivery in African American and American Indian or Alaska Native patients: A real-world cohort study.

BMC nephrology
BACKGROUND: Racially minoritized populations in the United States (US), notably African American (AA) and American Indian/Alaska Native (AI/AN), experience disproportionately higher rates of chronic kidney disease (CKD), diabetes, and hypertension co...

Plasma Metabolomics and Machine Learning Reveals Metabolic Alterations and Diagnostic Biomarkers for Deep Venous Thrombosis in Hypertensive Patients after Traumatic Fracture.

Journal of proteome research
We aimed to explore the metabolic dysregulations and diagnostic biomarkers for post-traumatic deep venous thrombosis (pt-DVT) in hypertensive (HPT) patients after fracture. An untargeted ultraperformance liquid chromatography-mass spectrometry-based ...

ML enhanced bioactivity prediction for angiotensin II receptor: A potential anti-hypertensive drug target.

Scientific reports
The process of drug discovery is intricate, and encompasses a series of detailed phases of research, development, and testing, aimed at evaluating the safety and effectiveness of prospective therapeutic agents. Artificial Intelligence has emerged as ...

Unsupervised learning using EHR and census data to identify distinct subphenotypes of newly diagnosed hypertension patients.

PloS one
BACKGROUND: Hypertension (HTN) is a complex condition with significant heterogeneity in presentation and treatment response. Identifying distinct subphenotypes of HTN may improve our understanding of its underlying mechanisms and guide more precise t...

Network-based machine learning reveals cardiometabolic multimorbidity patterns and modifiable lifestyle factors: a community-focused analysis of NHANES 2015-2018.

BMC public health
Cardiometabolic Multimorbidity (CMM) has emerged as one of the primary threats to human health globally due to its high incidence, disability, and mortality rates. Accurate identification of CMM patterns is crucial for CMM classification and health m...

Multi-datasets transfer multitask learning for simultaneous blood glucose and blood pressure monitoring using common PPG features.

Computers in biology and medicine
The simultaneous monitoring of both blood glucose level (BGL) and blood pressure (BP) has rarely been studied directly. The exploitation of physiological interactions between them will advance the learning of either task. However, the lack of availab...

Out-of-distribution reject option method for dataset shift problem in early disease onset prediction.

Scientific reports
Machine learning is increasingly used to predict lifestyle-related disease onset using health and medical data. However, its predictive accuracy for use is often hindered by dataset shift, which refers to discrepancies in data distribution between th...

Diagnostic and prognostic value of ECG-predicted hypertension-mediated left ventricular hypertrophy using machine learning.

Journal of hypertension
OBJECTIVE: Four hypertension-mediated left ventricular hypertrophy (LVH) phenotypes have been reported using cardiac magnetic resonance (CMR): normal LV, LV remodelling, eccentric and concentric LVH, with varying prognostic implications. The electroc...