AIMC Topic: Knowledge Bases
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ProbOnto: ontology and knowledge base of probability distributions.
Bioinformatics (Oxford, England)
Apr 3, 2016
MOTIVATION: Probability distributions play a central role in mathematical and statistical modelling. The encoding, annotation and exchange of such models could be greatly simplified by a resource providing a common reference for the definition of pro...
An automated knowledge-based textual summarization system for longitudinal, multivariate clinical data.
Journal of biomedical informatics
Mar 30, 2016
OBJECTIVES: Design and implement an intelligent free-text summarization system: The system's input includes large numbers of longitudinal, multivariate, numeric and symbolic clinical raw data, collected over varying periods of time, and in different ...
Bridging the gap between formal and experience-based knowledge for context-aware laparoscopy.
International journal of computer assisted radiology and surgery
Mar 30, 2016
PURPOSE: Computer assistance is increasingly common in surgery. However, the amount of information is bound to overload processing abilities of surgeons. We propose methods to recognize the current phase of a surgery for context-aware information fil...
PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability.
Journal of the American Medical Informatics Association : JAMIA
Mar 28, 2016
OBJECTIVE: Health care generated data have become an important source for clinical and genomic research. Often, investigators create and iteratively refine phenotype algorithms to achieve high positive predictive values (PPVs) or sensitivity, thereby...
Extracting genetic alteration information for personalized cancer therapy from ClinicalTrials.gov.
Journal of the American Medical Informatics Association : JAMIA
Mar 24, 2016
OBJECTIVE: Clinical trials investigating drugs that target specific genetic alterations in tumors are important for promoting personalized cancer therapy. The goal of this project is to create a knowledge base of cancer treatment trials with annotati...
REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.
Scientific reports
Mar 15, 2016
Regeneration is a common phenomenon across multiple animal phyla. Regeneration-related genes (REGs) are critical for fundamental cellular processes such as proliferation and differentiation. Identification of REGs and elucidating their functions may ...
Long Term Effect on Professionals' Knowledge, Practice and Attitudes towards User Involvement Four Years after Implementing an Organisational Development Plan: A Controlled Study.
PloS one
Mar 14, 2016
BACKGROUND: Health service organisations are increasingly implementing user involvement initiatives according to requirements from governments, such as user representation in administrational boards, better information to users, and more involvement ...
UniProt-DAAC: domain architecture alignment and classification, a new method for automatic functional annotation in UniProtKB.
Bioinformatics (Oxford, England)
Mar 7, 2016
MOTIVATION: Similarity-based methods have been widely used in order to infer the properties of genes and gene products containing little or no experimental annotation. New approaches that overcome the limitations of methods that rely solely upon sequ...
Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.
Regulatory toxicology and pharmacology : RTP
Feb 13, 2016
Statistical-based and expert rule-based models built using public domain mutagenicity knowledge and data are routinely used for computational (Q)SAR assessments of pharmaceutical impurities in line with the approach recommended in the ICH M7 guidelin...
Comparison of Planning Quality and Efficiency Between Conventional and Knowledge-based Algorithms in Nasopharyngeal Cancer Patients Using Intensity Modulated Radiation Therapy.
International journal of radiation oncology, biology, physics
Feb 12, 2016
PURPOSE: Intensity modulated radiation therapy (IMRT) is widely used to achieve a highly conformal dose and improve treatment outcome. However, plan quality and planning time are institute and planner dependent, and no standardized tool exists to rec...
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