AIMC Topic: Quinazolines

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ML-based prediction to experimental validation: Development of dihydroquinazoline based multi-potent ligands as anti-Alzheimer's agents.

Computers in biology and medicine Jul 14, 2025
Alzheimer's disease (AD) is a multifactorial neurological disorder accounting for the cognitive decline in the patients. The disease is linked to numerous pathological factors including hyperactivation of acetylcholinesterase (AChE) and monoamine oxi...
Ligands Acetylcholinesterase Amyloid beta-Peptides Alzheimer Disease Quinazolines Monoamine Oxidase Inhibitors Cholinesterase Inhibitors Monoamine Oxidase Humans Machine Learning Molecular Docking Simulation
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Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects.

Molecular medicine reports Apr 1, 2022
Evodiamine (Evo) is an alkaloid that can be extracted from the berry fruit and has been reported to exert various pharmacological effects, such as antidiarrheal, antiemetic and antiulcer effects. , the potential effects of Evo were investigated in a...
Dextran Sulfate Anti-Inflammatory Agents Quinazolines Colitis, Ulcerative Colorectal Neoplasms Animals Mice Colon Mice, Inbred C57BL
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Efficacy according to blind independent central review: Post-hoc analyses from the phase III, randomized, multicenter, IPASS study of first-line gefitinib versus carboplatin/paclitaxel in Asian patients with EGFR mutation-positive advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) Nov 30, 2016
OBJECTIVE: The Phase III, randomized, open-label IPASS study (NCT00322452) of first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) gefitinib versus carboplatin/paclitaxel for Asian patients with advanced non-small-cell lun...
Disease-Free Survival Smoking ErbB Receptors Protein Kinase Inhibitors Carboplatin Paclitaxel Asian People Antineoplastic Combined Chemotherapy Protocols Quinazolines Gefitinib Adenocarcinoma Neoplasm Staging Female Lung Neoplasms Middle Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung Mutation Aged Antineoplastic Agents Male Humans Randomized Controlled Trials as Topic
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Disentangling multidimensional spatio-temporal data into their common and aberrant responses.

PloS one Apr 22, 2015
With the advent of high-throughput measurement techniques, scientists and engineers are starting to grapple with massive data sets and encountering challenges with how to organize, process and extract information into meaningful structures. Multidime...
Breast Neoplasms Biomarkers, Tumor Female Principal Component Analysis Mutation Gene Regulatory Networks Gene Expression Regulation, Neoplastic Humans Neural Networks, Computer Algorithms Lapatinib Protein Array Analysis Quinazolines Proto-Oncogene Proteins c-akt
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