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Large Language Models

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Impact of large language model (ChatGPT) in healthcare: an umbrella review and evidence synthesis.

Journal of biomedical science
BACKGROUND: The emergence of Artificial Intelligence (AI), particularly Chat Generative Pre-Trained Transformer (ChatGPT), a Large Language Model (LLM), in healthcare promises to reshape patient care, clinical decision-making, and medical education. ...

Rising Influence of Artificial Intelligence: Trends in Large Language Model Usage in Dermatology Residency Personal Statements.

Journal of drugs in dermatology : JDD
With the public release of ChatGPT before the 2024 dermatology residency application cycle, applicants gained access to an advanced language model capable of generating or enhancing personal statements. This study examines trends in artificial intell...

Leveraging large language models to compare perspectives on integrating QSP and AI/ML.

Journal of pharmacokinetics and pharmacodynamics
Two recent papers offer contrasting perspectives on integrating Quantitative Systems Pharmacology (QSP) and Artificial Intelligence/Machine Learning (AI/ML): one views QSP as the primary driver using AI/ML to enhance computational tasks, while the ot...

Streamlining systematic reviews with large language models using prompt engineering and retrieval augmented generation.

BMC medical research methodology
BACKGROUND: Systematic reviews (SRs) are essential to formulate evidence-based guidelines but require time-consuming and costly literature screening. Large Language Models (LLMs) can be a powerful tool to expedite SRs.

Derivational morphology reveals analogical generalization in large language models.

Proceedings of the National Academy of Sciences of the United States of America
What mechanisms underlie linguistic generalization in large language models (LLMs)? This question has attracted considerable attention, with most studies analyzing the extent to which the language skills of LLMs resemble rules. As of yet, it is not k...

Exploratory Analysis of Nationwide Japanese Patient Safety Reports on Suicide and Suicide Attempts Among Inpatients With Cancer Using Large Language Models.

Psycho-oncology
OBJECTIVE: Patients with cancer have a high risk of suicide. However, evidence-based preventive measures remain unclear. This study aimed to investigate suicide prevention strategies for hospitalized patients with cancer by analyzing nationwide patie...

The influence of prompt engineering on large language models for protein-protein interaction identification in biomedical literature.

Scientific reports
Identifying protein-protein interactions (PPIs) is a foundational task in biomedical natural language processing. While specialized models have been developed, the potential of general-domain large language models (LLMs) in PPI extraction, particular...

Global Health care Professionals' Perceptions of Large Language Model Use In Practice: Cross-Sectional Survey Study.

JMIR medical education
BACKGROUND: ChatGPT is a large language model-based chatbot developed by OpenAI. ChatGPT has many potential applications to health care, including enhanced diagnostic accuracy and efficiency, improved treatment planning, and better patient outcomes. ...

Evaluation and Bias Analysis of Large Language Models in Generating Synthetic Electronic Health Records: Comparative Study.

Journal of medical Internet research
BACKGROUND: Synthetic electronic health records (EHRs) generated by large language models (LLMs) offer potential for clinical education and model training while addressing privacy concerns. However, performance variations and demographic biases in th...

The Applications of Large Language Models in Mental Health: Scoping Review.

Journal of medical Internet research
BACKGROUND: Mental health is emerging as an increasingly prevalent public issue globally. There is an urgent need in mental health for efficient detection methods, effective treatments, affordable privacy-focused health care solutions, and increased ...