Aging leads to age-related pathology that causes death, and genes affect lifespan by determining such pathology. Here we investigate how age-related pathology mediates the effect of genetic and environmental interventions on lifespan in C. elegans by...
The cerebellar vermis undergoes diverse structural changes with aging, yet region-specific aging patterns remain underexplored. Using Brain Structure Age (BSA), a deep learning biomarker from structural magnetic resonance imaging (MRI), we aimed to: ...
BACKGROUND: Cognitive impairment, indicative of Alzheimer disease and other forms of dementia, significantly deteriorates the quality of life of older adult populations and imposes considerable burdens on families and health care systems worldwide. T...
Unhealthy lifestyle behaviors are a doorway to downstream health consequences characterized by the following: 1) poor quality of life and diminished mobility; 2) increased likelihood of chronic disease risk factors and diagnoses; and, ultimately, 3) ...
With the global population aging at an unprecedented rate, there is a need to extend healthy productive life span. This review examines how Deep Learning (DL) and Generative Artificial Intelligence (GenAI) are used in biomarker discovery, deep aging ...
Biological aging clocks produce age estimates that can track with age-related health outcomes. This study aimed to benchmark machine learning algorithms, including regularized regression, kernel-based methods, and ensembles, for developing metabolomi...
The field of aging and longevity research is overwhelmed by vast amounts of data, calling for the use of Artificial Intelligence (AI), including Large Language Models (LLMs), for the evaluation of geroprotective interventions. Such evaluations should...
Aging involves metabolic changes that lead to reduced cellular fitness, yet the role of many metabolites in aging is unclear. Understanding the mechanisms of known geroprotective molecules reveals insights into metabolic networks regulating aging and...
The American journal of bioethics : AJOB
Nov 14, 2024
There is an ongoing debate about the ethics of research on lifespan extension: roughly, using medical technologies to extend biological human lives beyond the current "natural" limit of about 120 years. At the same time, there is an exploding interes...
BACKGROUND: Loneliness is prevalent among the elderly and has intensified due to global aging trends. It adversely affects both mental and physical health. Traditional scales for measuring loneliness may yield biased results due to varying definition...
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