OBJECTIVES: Achieving optimal adherence to antiretroviral therapy (ART) and viral suppression is still insufficient for attaining the UNAIDS 95-95-95 target of 2030, especially among adolescents with HIV (AWHIV). This study sought to develop a model ...
Proceedings of the National Academy of Sciences of the United States of America
Feb 24, 2025
Brain age (BA), distinct from chronological age (CA), can be estimated from MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative neuroanatomic aging since bi...
Proceedings of the National Academy of Sciences of the United States of America
Feb 20, 2025
Longitudinal imaging data are routinely acquired for health studies and patient monitoring. A central goal in longitudinal studies is tracking relevant change over time. Traditional methods remove nuisance variation with custom pipelines to focus on ...
Journal of child psychology and psychiatry, and allied disciplines
Feb 18, 2025
BACKGROUND: Early identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large-scale electronic health record (EHR) data including clinical n...
BACKGROUND: Given the accelerated aging population in China, the number of disabled elderly individuals is increasing, and depression is a common mental disorder among older adults. This study aims to establish an effective model for predicting depre...
BACKGROUND: Early diagnosis and accurate prognosis of cognitive decline in Alzheimer's disease (AD) is important to timely assignment to optimal treatment modes. We aimed to develop a deep learning model to predict cognitive conversion to guide re-as...
BACKGROUND: Due to the ageing population and evolving lifestyles occurring in China, middle-aged and elderly populations have become high-risk groups for cardiovascular disease (CVD). The aim of this study was to analyse the incidence characteristics...
The journal of prevention of Alzheimer's disease
Feb 6, 2025
BACKGROUND: Mild cognitive impairment (MCI) and preclinical MCI (e.g., subjective cognitive decline, SCD) are considered risk states of dementia, such as Alzheimer's Disease (AD). However, it is challenging to accurately predict conversion from norma...
INTRODUCTION: Speech impediments (SIs) are increasingly prevalent among middle-aged and older adults, raising concerns within public health. Early detection of potential SI in this demographic is critical. This study investigates the potential of Act...
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