AIMC Topic: Lysine

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Deep-Kcr: accurate detection of lysine crotonylation sites using deep learning method.

Briefings in bioinformatics Jul 20, 2021
As a newly discovered protein posttranslational modification, histone lysine crotonylation (Kcr) involved in cellular regulation and human diseases. Various proteomics technologies have been developed to detect Kcr sites. However, experimental approa...
Humans Deep Learning Protein Processing, Post-Translational Databases, Protein Lysine Sequence Analysis, Protein Acylation Crotonates
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Deep learning based prediction of reversible HAT/HDAC-specific lysine acetylation.

Briefings in bioinformatics Sep 25, 2020
Protein lysine acetylation regulation is an important molecular mechanism for regulating cellular processes and plays critical physiological and pathological roles in cancers and diseases. Although massive acetylation sites have been identified throu...
Humans Neoplasms Deep Learning Internet Datasets as Topic Acetylation Lysine Histone Deacetylases
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Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework.

Briefings in bioinformatics Nov 27, 2019
As a newly discovered post-translational modification (PTM), lysine malonylation (Kmal) regulates a myriad of cellular processes from prokaryotes to eukaryotes and has important implications in human diseases. Despite its functional significance, com...
Humans Machine Learning Animals Computational Biology Lysine Malonates
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Large-scale comparative assessment of computational predictors for lysine post-translational modification sites.

Briefings in bioinformatics Nov 27, 2019
Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse functions and biological processes of proteins. However, because of the large volumes of sequencing data generated from genome-sequencing projects, systematic id...
Machine Learning Algorithms Computational Biology Protein Processing, Post-Translational Feasibility Studies Lysine
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LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.

Oncotarget Nov 24, 2015
Accumulating evidences suggest that long non-coding RNAs (lncRNAs) perform important functions. Genome-wide chromatin-states area rich source of information about cellular state, yielding insights beyond what is typically obtained by transcriptome pr...
Humans Algorithms Cells, Cultured Neoplasms Gene Expression Profiling Cell Line, Tumor Gene Regulatory Networks RNA, Messenger Models, Genetic Hep G2 Cells Cell Line RNA, Long Noncoding HeLa Cells Methylation Promoter Regions, Genetic Lysine K562 Cells Histones Gene Ontology Chromatin Transcription Initiation Site
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