BACKGROUND: Disappointing medical care (DMC) encompasses cases of medical failures, malpractice, or errors. Literature suggests that individuals' perceptions of harm resulting from medical procedures influence their intention to seek legal recourse a...
Gastric cancer (GC) is a highly heterogeneous disease that requires highly accurate prognostic models. Machine learning is a powerful tool for identifying predictive biomarkers and developing prognostic models. Here, we aim to integrate bioinformatic...
Environmental geochemistry and health
Oct 14, 2025
Water quality and quantity affect crop productivity, with surface water quality having a significant impact. The amount of surface water being used for drinking is gradually rising. Thus, assessing surface water quality and related hydro-chemical cha...
This study presents a machine learning-driven model predicting all-cause mortality two years in advance using administrative health data focused on diabetic patients. Integrating hospitalization records, emergency department data, demographics, and c...
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder that affects both motor and cognitive functions, particularly working memory (WM). Machine learning offers an advantage for decoding complex brain activity patterns, but its applica...
Zhao et al. present machine-learning models to predict intraoperative hemodynamic instability in hypertensive pheochromocytoma and paraganglioma surgery. The clinical motivation is sound and the reported discrimination and decision-curve metrics indi...
BACKGROUND: Artificial intelligence (AI) is increasingly being integrated into clinical diagnostics; yet, its lack of transparency hinders trust and adoption among health care professionals. The explainable artificial intelligence (XAI) has the poten...
Journal of chemical information and modeling
Oct 13, 2025
β-Arrestins (βarr1 and βarr2) are key transducers of G protein-coupled receptor (GPCR) signaling, orchestrating both shared and isoform-specific intracellular pathways. Phosphorylation of the receptor C-terminal tail by GPCR kinases encodes regulator...
G-protein-coupled receptors (GPCRs) are pivotal in cellular signal transduction and serve as key drug targets. Among them, the β-adrenergic receptors (βAR and βAR) regulate cardiovascular function and are activated by endogenous catecholamines, norep...
BMC medical informatics and decision making
Oct 13, 2025
BACKGROUND: Clinical utilization of machine learning is hampered by the lack of interpretability inherent in most non-linear black box modeling approaches, reducing trust among clinicians and regulators. Advanced large language models offer a potenti...
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