Archives of gynecology and obstetrics
Feb 19, 2021
PURPOSE: Applying machine-learning models to clinical and laboratory features of women with intrahepatic cholestasis of pregnancy (ICP) and creating algorithm to identify these patients without bile acid measurements.
Quantitative analysis of complex mixtures is a great challenge for spectral analysis. Bisphenol A (BpA) is a chemical predominantly used in manufacturing and is being replaced by other analogs due to its potential toxicity. Reliability methods is hen...
While hundreds of genes have been associated with pain, much of the molecular mechanisms of pain remain unknown. As a result, current analgesics are limited to few clinically validated targets. Here, we trained a machine learning (ML) ensemble model ...
Antimicrobial resistance is a major global health threat and its development is promoted by antibiotic misuse. While disk diffusion antibiotic susceptibility testing (AST, also called antibiogram) is broadly used to test for antibiotic resistance in ...
COVID-19 cases are exponentially increasing worldwide; however, its clinical phenotype remains unclear. Natural language processing (NLP) and machine learning approaches may yield key methods to rapidly identify individuals at a high risk of COVID-19...
BACKGROUND: Identifying individuals at risk for future hospitalization or death has been a major priority of population health management strategies. High-risk individuals are a heterogeneous group, and existing studies describing heterogeneity in hi...
Bioorganic & medicinal chemistry letters
Feb 18, 2021
De novo design of mini-proteins (4-12 kDa) has recently been shown to produce new candidates for protein therapeutics. They are temperature stable molecules that bind to the drug target with high affinity for inhibiting its interactions. The developm...
BACKGROUND: Despite a large body of literature investigating how the environment influences health outcomes, most published work to date includes only a limited subset of the rich clinical and environmental data that is available and does not address...
BACKGROUND AND PURPOSE: Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage negatively impacts long-term recovery but is often detected too late to prevent damage. We aim to develop hourly risk scores using routinely collected cl...
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