Structure (London, England : 1993)
Jun 16, 2025
Biomolecular force fields have continuously evolved to improve their accuracy and broaden their applications in biological and therapeutic discoveries. The rapid adaptation of advanced computational technology, in particular the recent deep learning ...
The journal of physical chemistry letters
Jun 16, 2025
Atomic charge is crucial in drug design for analyzing reactive sites and interactions between ligands and targets. While quantum mechanical methods offer high accuracy, they are generally computationally costly. Conversely, empirical approaches, whil...
European journal of medical research
Jun 16, 2025
OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation.
Mikrochimica acta
Jun 16, 2025
Cancer remains one of the most deadly diseases in the world, requiring constant growth and improvements in therapeutic strategies. Traditional cancer treatments, such as chemotherapy, radiotherapy, and surgery, have limitations like off-target releas...
Scientific reports
Jun 16, 2025
Dysarthria frequently occurs in individuals with disorders such as stroke, Parkinson's disease, cerebral palsy, and other neurological disorders. Well-timed detection and management of dysarthria in these patients is imperative for efficiently handli...
Anais da Academia Brasileira de Ciencias
Jun 16, 2025
This research focuses on predicting cardiovascular disease using machine learning classification strategies. The study presents a unique approach by integrating multiple machine learning techniques, leveraging the strengths of Random Forest and Gradi...
Food chemistry
Jun 15, 2025
Food safety challenges escalate with global population growth and complex supply chains. Traditional analytical methods, though precise, face limitations in speed and adaptability. Machine learning (ML) offers data-driven solutions, excelling in cont...
The journal of physical chemistry letters
Jun 15, 2025
Accurate and early detection of C-peptide, a stable biomarker indicative of diabetes, is crucial for disease diagnosis, treatment, and prevention. This study explores a novel detection methodology using solid-state nanopore technology coupled with ma...
Epigenetics & chromatin
Jun 14, 2025
DNA methylation is a fundamental epigenetic modification that regulates gene expression and maintains genomic stability. Consequently, DNA methylation remains a key biomarker in cancer research, playing a vital role in diagnosis, prognosis, and tailo...
Clinical and experimental medicine
Jun 14, 2025
The SARS-CoV-2 RNA virus, with its rapid spread and frequent genetic changes, has posed unparalleled obstacles for public health and treatment efforts. Early diagnosis of the disease and the development of effective treatment strategies are the main ...