Human dihydroorotate dehydrogenase (hDHODH) is a flavin mononucleotide-dependent enzyme that can limit de novo pyrimidine synthesis, making it a therapeutic target for diseases such as autoimmune disorders and cancer. In this study, using the docking...
Neural networks : the official journal of the International Neural Network Society
Sep 26, 2024
Multi-relational graph learning aims to embed entities and relations in knowledge graphs into low-dimensional representations, which has been successfully applied to various multi-relationship prediction tasks, such as information retrieval, question...
OBJECTIVES: The paper develops a machine learning-based safety index for classifying traffic conflicts that can be used to estimate the frequency of signalized intersection crashes, with a focus on the more severe ones that result in fatal and severe...
Heterogeneous activation of peracetic acid (PAA) process is a promising method for removing organic pollutants from water. Nevertheless, this process is constrained by several complex factors, such as the selection of catalysts, optimization of react...
Influenza is a disease that represents both a public health and agricultural risk with pandemic potential. Among the subtypes of influenza A virus, H3 influenza virus can infect many avian and mammalian species and is therefore a virus of interest to...
Best practice & research. Clinical rheumatology
Sep 26, 2024
Technological advances and high-throughput bio-chemical assays are rapidly changing ways how we formulate and test biological hypotheses, and how we treat patients. Most complex diseases arise on a background of genetics, lifestyle and environment fa...
The study of fetal gut development is critical due to its substantial influence on immediate neonatal and long-term adult health. Current research largely focuses on microbiome colonization, gut immunity, and barrier function, alongside the impact of...
PURPOSE: Pancreatic cancer is a lethal type of cancer with most of the cases being diagnosed in an advanced stage and poor prognosis. Developing new diagnostic and prognostic markers for pancreatic cancer can significantly improve early detection and...
Nanomedicine : nanotechnology, biology, and medicine
Sep 26, 2024
Atherosclerotic carotid stenosis (ACS) is a recognized risk factor for ischemic stroke. Currently, the gold diagnostic standard is Doppler ultrasound, the results of which do not provide certainty whether a given person should be qualified for surger...
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