AIMC Topic: Matrix Metalloproteinase Inhibitors

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Machine learning and biological evaluation-based identification of a potential MMP-9 inhibitor, effective against ovarian cancer cells SKOV3.

Journal of biomolecular structure & dynamics Jul 28, 2023
MMP-9, also known as gelatinase B, is a zinc-metalloproteinase family protein that plays a key role in the degradation of the extracellular matrix (ECM). The normal function of MMP-9 includes the breakdown of ECM, a process that aids in normal physio...
Molecular Docking Simulation Antineoplastic Agents Machine Learning Female Ovarian Neoplasms Matrix Metalloproteinase Inhibitors Cell Line, Tumor Cell Proliferation Humans
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ASAP-SML: An antibody sequence analysis pipeline using statistical testing and machine learning.

PLoS computational biology Apr 27, 2020
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of ant...
Software Algorithms Humans Machine Learning Matrix Metalloproteinases Databases, Protein Sequence Analysis, Protein Computational Biology Matrix Metalloproteinase Inhibitors Antibodies
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Prediction of matrix metal proteinases-12 inhibitors by machine learning approaches.

Journal of biomolecular structure & dynamics Dec 24, 2018
Matrix metal proteinases-12 (MMP-12) is a hot pharmaceutical target on the treatment of many human diseases. There's a crying need for designing and finding new MMP-12 inhibitors. In this work, four machine learning approaches, support vector machine...
Matrix Metalloproteinase Inhibitors Matrix Metalloproteinase 12 Quantitative Structure-Activity Relationship Drug Discovery ROC Curve Support Vector Machine Molecular Structure Algorithms Reproducibility of Results Machine Learning
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Phase 1b Study of the Safety, Pharmacokinetics, and Disease-related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis.

Clinical therapeutics Dec 26, 2017
PURPOSE: Andecaliximab (GS-5745) is a highly selective monoclonal antibody against matrix metalloproteinase-9 (MMP9), a proteolytic enzyme implicated in the pathogenesis of rheumatoid arthritis (RA). This study assessed the safety and pharmacokinetic...
Female Aged Male Middle Aged Humans Antibodies, Monoclonal Infusions, Intravenous Arthritis, Rheumatoid Antirheumatic Agents Antibodies, Monoclonal, Humanized Matrix Metalloproteinase Inhibitors Double-Blind Method Matrix Metalloproteinase 9
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Selected essential oils inhibit key physiological enzymes and possess intracellular and extracellular antimelanogenic properties in vitro.

Journal of food and drug analysis Apr 20, 2017
Essential oils (EOs) extracted from six medicinal herbs and food plants [Cinnamomum zeylanicum (CZ), Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), and Citrus reticulata (CR)] were studied for any inhibitor...
Plants, Medicinal Melanoma, Experimental Cholinesterase Inhibitors Mice Matrix Metalloproteinase Inhibitors Gene Expression Regulation, Enzymologic Animals Collagenases Plant Extracts Humans Biosynthetic Pathways Oils, Volatile Hypoglycemic Agents Enzyme Inhibitors Kinetics Melanins
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