Keratoconus (KC) is a progressive corneal disorder characterized by thinning of the cornea and conical protrusion leading to distorted vision and blindness. The disease often marks in adolescence and progresses until the mid-40s, with varying degrees...
International journal of biological macromolecules
Jul 28, 2025
Enzyme-triggered polymersomes have emerged as a transformative platform in liquid biopsy and cancer diagnostics, enabling high-accuracy biomarker detection through precise enzymatic responsiveness. This review comprehensively examines the rational de...
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of ant...
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced proteomic technologies...
OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its possible mechanisms in vitro.
INTRODUCTION: Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone...
Automated technologies that can perform massively parallelized and sequential fluidic operations at small length scales can resolve major bottlenecks encountered in various fields, including medical diagnostics, -omics, drug development, and chemical...
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