AIMC Topic: Matrix Metalloproteinases
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Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sep 17, 2020
In the present study, the protective effects of myricitrin against vascular endothelial growth factor (VEGF)-induced angiogenesis of vascular endothelial cells were characterized. Cells were induced with 50 ng/mL VEGF in the presence or absence of va...
Neovascularization, Physiologic
Vascular Endothelial Growth Factors
Xenograft Model Antitumor Assays
Matrix Metalloproteinases
Neovascularization, Pathologic
Angiogenesis Inhibitors
Animals
Disease Models, Animal
Cell Line, Tumor
Apoptosis
Mice
Humans
Flavonoids
Biomarkers
Human Umbilical Vein Endothelial Cells
Caspases
ASAP-SML: An antibody sequence analysis pipeline using statistical testing and machine learning.
PLoS computational biology
Apr 27, 2020
Antibodies are capable of potently and specifically binding individual antigens and, in some cases, disrupting their functions. The key challenge in generating antibody-based inhibitors is the lack of fundamental information relating sequences of ant...
Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-B Pathway.
BioMed research international
Dec 3, 2017
BACKGROUND: Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1-stimulated chondrocytes are unclear.
Knowledge-transfer learning for prediction of matrix metalloprotease substrate-cleavage sites.
Scientific reports
Jul 18, 2017
Matrix Metalloproteases (MMPs) are an important family of proteases that play crucial roles in key cellular and disease processes. Therefore, MMPs constitute important targets for drug design, development and delivery. Advanced proteomic technologies...
The protective effects of bone morphogenetic protein-7 against epithelial injury and matrix metalloproteases upregulation induced by silica in vitro.
Human & experimental toxicology
Oct 20, 2016
OBJECTIVE: We investigate the effects of bone morphogenetic protein-7 (BMP-7) on models with silica-induced and macrophage-mediated fibrosis and its possible mechanisms in vitro.
Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets.
Cancer medicine
May 1, 2025
INTRODUCTION: Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone...
A ferrobotic system for automated microfluidic logistics.
Science robotics
Feb 26, 2020
Automated technologies that can perform massively parallelized and sequential fluidic operations at small length scales can resolve major bottlenecks encountered in various fields, including medical diagnostics, -omics, drug development, and chemical...
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