AIMC Topic: Microfluidics
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Stretchable pumps for soft machines.
Nature
Aug 15, 2019
Machines made of soft materials bridge life sciences and engineering. Advances in soft materials have led to skin-like sensors and muscle-like actuators for soft robots and wearable devices. Flexible or stretchable counterparts of most key mechatroni...
The optoelectronic microrobot: A versatile toolbox for micromanipulation.
Proceedings of the National Academy of Sciences of the United States of America
Jul 9, 2019
Microrobotics extends the reach of human-controlled machines to submillimeter dimensions. We introduce a microrobot that relies on optoelectronic tweezers (OET) that is straightforward to manufacture, can take nearly any desirable shape or form, and ...
Automated System for Small-Population Single-Particle Processing Enabled by Exclusive Liquid Repellency.
SLAS technology
Jun 10, 2019
Exclusive liquid repellency (ELR) describes an extreme wettability phenomenon in which a liquid phase droplet is completely repelled from a solid phase when exposed to a secondary immiscible liquid phase. Earlier, we developed a multi-liquid-phase op...
3D Fabrication of Fully Iron Magnetic Microrobots.
Small (Weinheim an der Bergstrasse, Germany)
Mar 4, 2019
Biocompatibility and high responsiveness to magnetic fields are fundamental requisites to translate magnetic small-scale robots into clinical applications. The magnetic element iron exhibits the highest saturation magnetization and magnetic susceptib...
Deep Learning with Microfluidics for Biotechnology.
Trends in biotechnology
Oct 6, 2018
Advances in high-throughput and multiplexed microfluidics have rewarded biotechnology researchers with vast amounts of data but not necessarily the ability to analyze complex data effectively. Over the past few years, deep artificial neural networks ...
Kernel-Based Microfluidic Constriction Assay for Tumor Sample Identification.
ACS sensors
Jul 18, 2018
A high-throughput multiconstriction microfluidic channels device can distinguish human breast cancer cell lines (MDA-MB-231, HCC-1806, MCF-7) from immortalized breast cells (MCF-10A) with a confidence level of ∼81-85% at a rate of 50-70 cells/min bas...
Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery.
Small (Weinheim an der Bergstrasse, Germany)
May 8, 2018
The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte,...
Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.
Scientific reports
Sep 29, 2017
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...
Multiparameter mechanical and morphometric screening of cells.
Scientific reports
Dec 2, 2016
We introduce a label-free method to rapidly phenotype and classify cells purely based on physical properties. We extract 15 biophysical parameters from cells as they deform in a microfluidic stretching flow field via high-speed microscopy and apply m...
tarSVM: Improving the accuracy of variant calls derived from microfluidic PCR-based targeted next generation sequencing using a support vector machine.
BMC bioinformatics
Jun 10, 2016
BACKGROUND: Targeted sequencing of discrete gene sets is a cost effective strategy to screen subjects for monogenic forms of disease. One method to achieve this pairs microfluidic PCR with next generation sequencing. The PCR step of this pipeline cre...
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