AI Medical Compendium Topic

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Surrogate Simulation of Subject-Specific Lateral Pinch via Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Musculoskeletal modeling and simulation is often a lengthy and computationally expensive process, particularly when developing and using personalized models. We present a deep learning-based adaptive surrogate model for lateral pinch, which accepts b...

Simulation of a Free Boundary Cell Migration Model through Physics Informed Neural Networks.

Journal of the mechanical behavior of biomedical materials
Understanding the complexities of single-cell migration is facilitated by computational modeling, which provides important insights into the physiological processes that underlie migration mechanisms. This study developed a computational model for on...

Predicting Pharmacokinetics in Rats Using Machine Learning: A Comparative Study Between Empirical, Compartmental, and PBPK-Based Approaches.

Clinical and translational science
A successful drug needs to combine several properties including high potency and good pharmacokinetic (PK) properties to sustain efficacious plasma concentration over time. To estimate required doses for preclinical animal efficacy models or for the ...

Biological age prediction using a DNN model based on pathways of steroidogenesis.

Science advances
Aging involves the progressive accumulation of cellular damage, leading to systemic decline and age-related diseases. Despite advances in medicine, accurately predicting biological age (BA) remains challenging due to the complexity of aging processes...

Machine learning-derived diagnostic model of epithelial ovarian cancer based on gut microbiome signatures.

Journal of translational medicine
BACKGROUND: Prior studies have elucidated that alterations in gut microbiota are associated with a spectrum of tumors and metabolic disorders. However, the diagnostic value of gut microbiota in epithelial ovarian cancer remains insufficiently investi...

Control of medical digital twins with artificial neural networks.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
The objective of precision medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be personalized and dyn...

Predicting the diversity of photosynthetic light-harvesting using thermodynamics and machine learning.

PLoS computational biology
Oxygenic photosynthesis is responsible for nearly all biomass production on Earth, and may have been a prerequisite for establishing a complex biosphere rich in multicellular life. Life on Earth has evolved to perform photosynthesis in a wide range o...

Soft robotic brittle star shows the influence of mass distribution on underwater walking.

Bioinspiration & biomimetics
Most walking organisms tend to have relatively light limbs and heavy bodies in order to facilitate rapid limb motion. However, the limbs of brittle stars (Class Ophiuroidea) are primarily comprised of dense skeletal elements, with potentially much hi...

RSM and AI based machine learning for quality by design development of rivaroxaban push-pull osmotic tablets and its PBPK modeling.

Scientific reports
The study is based on applying Artificial Neural Network (ANN) based machine learning and Response Surface Methodology (RSM) as simultaneous bivariate approaches in developing controlled-release rivaroxaban (RVX) osmotic tablets. The influence of dif...

Novel augmentation techniques using diffusion models for green wall plant health classification.

Computers in biology and medicine
Green walls, vertical plant-based structures, are increasingly popular due to their diverse environmental benefits, including aesthetic enhancement, temperature and humidity regulation, and air pollutant removal. These systems, typically consisting o...