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Models, Neurological

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Hopf Bifurcations in Directed Acyclic Networks of Linearly Coupled Hindmarsh-Rose Systems.

Acta biotheoretica
This paper addresses the existence of Hopf bifurcations in a directed acyclic network of neurons, each of them being modeled by a Hindmarsh-Rose (HR) neuronal model. The bifurcation parameter is the small parameter corresponding to the ratio of time ...

Developmental metaplasticity in neural circuit codes of firing and structure.

Neural networks : the official journal of the International Neural Network Society
Firing-rate dynamics have been hypothesized to mediate inter-neural information transfer in the brain. While the Hebbian paradigm, relating learning and memory to firing activity, has put synaptic efficacy variation at the center of cortical plastici...

Emergence of gamma motor activity in an artificial neural network model of the corticospinal system.

Journal of computational neuroscience
Muscle spindle discharge during active movement is a function of mechanical and neural parameters. Muscle length changes (and their derivatives) represent its primary mechanical, fusimotor drive its neural component. However, neither the action nor t...

Impaired neurogenesis of the dentate gyrus is associated with pattern separation deficits: A computational study.

Journal of integrative neuroscience
The separation of input patterns received from the entorhinal cortex (EC) by the dentate gyrus (DG) is a well-known critical step of information processing in the hippocampus. Although the role of interneurons in separation pattern efficiency of the ...

A Possible Neural Representation of Mathematical Group Structures.

Bulletin of mathematical biology
Every cognitive activity has a neural representation in the brain. When humans deal with abstract mathematical structures, for instance finite groups, certain patterns of activity are occurring in the brain that constitute their neural representation...

Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to ...

Demonstrating Hybrid Learning in a Flexible Neuromorphic Hardware System.

IEEE transactions on biomedical circuits and systems
We present results from a new approach to learning and plasticity in neuromorphic hardware systems: to enable flexibility in implementable learning mechanisms while keeping high efficiency associated with neuromorphic implementations, we combine a ge...

Driving reservoir models with oscillations: a solution to the extreme structural sensitivity of chaotic networks.

Journal of computational neuroscience
A large body of experimental and theoretical work on neural coding suggests that the information stored in brain circuits is represented by time-varying patterns of neural activity. Reservoir computing, where the activity of a recurrently connected p...

A neuromorphic model of motor overflow in focal hand dystonia due to correlated sensory input.

Journal of neural engineering
OBJECTIVE: Motor overflow is a common and frustrating symptom of dystonia, manifested as unintentional muscle contraction that occurs during an intended voluntary movement. Although it is suspected that motor overflow is due to cortical disorganizati...

Optogenetics in Silicon: A Neural Processor for Predicting Optically Active Neural Networks.

IEEE transactions on biomedical circuits and systems
We present a reconfigurable neural processor for real-time simulation and prediction of opto-neural behaviour. We combined a detailed Hodgkin-Huxley CA3 neuron integrated with a four-state Channelrhodopsin-2 (ChR2) model into reconfigurable silicon h...