AIMC Topic: Extracellular Fluid

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CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches.

PloS one Dec 23, 2024
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Rece...
Humans Brain Neoplasms Animals Cell Line, Tumor Nanoparticles Rats Cell Movement Neoplasm Invasiveness Glioblastoma Chemokine CXCL12 Receptors, CXCR4 Extracellular Fluid
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Predicting intratumoral fluid pressure and liposome accumulation using physics informed deep learning.

Scientific reports Nov 23, 2023
Liposome-based anticancer agents take advantage of the increased vascular permeability and transvascular pressure gradients for selective accumulation in tumors, a phenomenon known as the enhanced permeability and retention(EPR) effect. The EPR effec...
Animals Neoplasms Deep Learning Mice Extracellular Fluid Liposomes Physics
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Improved Perceptual Learning by Control of Extracellular GABA Concentration by Astrocytic Gap Junctions.

Neural computation Oct 24, 2017
Learning of sensory cues is believed to rely on synchronous pre- and postsynaptic neuronal firing. Evidence is mounting that such synchronicity is not merely caused by properties of the underlying neuronal network but could also depend on the integri...
Neural Networks, Computer Learning Animals Models, Neurological Extracellular Fluid Astrocytes Neurons Nonlinear Dynamics Perception gamma-Aminobutyric Acid Nerve Net Gap Junctions Membrane Potentials GABA Plasma Membrane Transport Proteins
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