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Models, Statistical

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Artificial Intelligence-Based Differential Diagnosis: Development and Validation of a Probabilistic Model to Address Lack of Large-Scale Clinical Datasets.

Journal of medical Internet research
BACKGROUND: Machine-learning or deep-learning algorithms for clinical diagnosis are inherently dependent on the availability of large-scale clinical datasets. Lack of such datasets and inherent problems such as overfitting often necessitate the devel...

Comparison of statistical and machine learning models for healthcare cost data: a simulation study motivated by Oncology Care Model (OCM) data.

BMC health services research
BACKGROUND: The Oncology Care Model (OCM) was developed as a payment model to encourage participating practices to provide better-quality care for cancer patients at a lower cost. The risk-adjustment model used in OCM is a Gamma generalized linear mo...

IOUC-3DSFCNN: Segmentation of Brain Tumors via IOU Constraint 3D Symmetric Full Convolution Network with Multimodal Auto-context.

Scientific reports
Accurate segmentation of brain tumors from magnetic resonance (MR) images play a pivot role in assisting diagnoses, treatments and postoperative evaluations. However, due to its structural complexities, e.g., fuzzy tumor boundaries with irregular sha...

Finding the needle in a high-dimensional haystack: Canonical correlation analysis for neuroscientists.

NeuroImage
The 21st century marks the emergence of "big data" with a rapid increase in the availability of datasets with multiple measurements. In neuroscience, brain-imaging datasets are more commonly accompanied by dozens or hundreds of phenotypic subject des...

A Novel Deep Neural Network for Robust Detection of Seizures Using EEG Signals.

Computational and mathematical methods in medicine
The detection of recorded epileptic seizure activity in electroencephalogram (EEG) segments is crucial for the classification of seizures. Manual recognition is a time-consuming and laborious process that places a heavy burden on neurologists, and he...

High-Resolution Motor State Detection in Parkinson's Disease Using Convolutional Neural Networks.

Scientific reports
Patients with advanced Parkinson's disease regularly experience unstable motor states. Objective and reliable monitoring of these fluctuations is an unmet need. We used deep learning to classify motion data from a single wrist-worn IMU sensor recordi...

LEAP: Using machine learning to support variant classification in a clinical setting.

Human mutation
Advances in genome sequencing have led to a tremendous increase in the discovery of novel missense variants, but evidence for determining clinical significance can be limited or conflicting. Here, we present Learning from Evidence to Assess Pathogeni...

Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury.

Journal of clinical epidemiology
OBJECTIVE: We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury.