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Artificial intelligence-based biomarkers for treatment decisions in oncology.

Trends in cancer
The development of new therapeutic strategies such as immune checkpoint inhibitors (ICIs) and targeted therapies has increased the complexity of the treatment landscape for solid tumors. At the current rate of annual FDA approvals, the potential trea...

Patients' attitudes toward artificial intelligence (AI) in cancer care: A scoping review protocol.

PloS one
BACKGROUND: Artificial intelligence broadly refers to computer systems that simulate intelligent behaviour with minimal human intervention. Emphasizing patient-centered care, research has explored patients' perspectives on artificial intelligence in ...

Larger sample sizes are needed when developing a clinical prediction model using machine learning in oncology: methodological systematic review.

Journal of clinical epidemiology
BACKGROUND AND OBJECTIVES: Having a sufficient sample size is crucial when developing a clinical prediction model. We reviewed details of sample size in studies developing prediction models for binary outcomes using machine learning (ML) methods with...

Application of deep learning in automated localization and interpretation of coronary artery calcification in oncological PET/CT scans.

The international journal of cardiovascular imaging
Coronary artery calcification (CAC) is a key marker of coronary artery disease (CAD) but is often underreported in cancer patients undergoing non-gated CT or PET/CT scans. Traditional CAC assessment requires gated CT scans, leading to increased radia...

Not seeing the trees for the forest. The impact of neighbours on graph-based configurations in histopathology.

BMC bioinformatics
BACKGROUND: Deep learning (DL) has set new standards in cancer diagnosis, significantly enhancing the accuracy of automated classification of whole slide images (WSIs) derived from biopsied tissue samples. To enable DL models to process these large i...

Interpretable identification of cancer genes across biological networks via transformer-powered graph representation learning.

Nature biomedical engineering
Graph representation learning has been leveraged to identify cancer genes from biological networks. However, its applicability is limited by insufficient interpretability and generalizability under integrative network analysis. Here we report the dev...

ImpACT Project: Improving Access to Clinical Trials in Victoria, an Artificial Intelligence-Based Approach.

JCO clinical cancer informatics
PURPOSE: Enhancing the speed and efficiency of clinical trial recruitment is a key objective across international health systems. This study aimed to use artificial intelligence (AI) applied in the Victorian Cancer Registry (VCR), a population-based ...

Advancing precision cancer immunotherapy drug development, administration, and response prediction with AI-enabled Raman spectroscopy.

Frontiers in immunology
Molecular characterization of tumors is essential to identify predictive biomarkers that inform treatment decisions and improve precision immunotherapy development and administration. However, challenges such as the heterogeneity of tumors and patien...

Sex-Based Bias in Artificial Intelligence-Based Segmentation Models in Clinical Oncology.

Clinical oncology (Royal College of Radiologists (Great Britain))
Artificial intelligence (AI) advancements have accelerated applications of imaging in clinical oncology, especially in revolutionizing the safe and accurate delivery of state-of-the-art imaging-guided radiotherapy techniques. However, concerns are gr...

Early identification of potentially reversible cancer cachexia using explainable machine learning driven by body weight dynamics: a multicenter cohort study.

The American journal of clinical nutrition
BACKGROUND: Cachexia is associated with multiple adverse outcomes in cancer. However, clinical decision-making for oncology patients at the cachexia stage presents significant challenges.