BMC bioinformatics
Jun 4, 2025
BACKGROUND: When genes are translated into proteins, mutations in the gene sequence can lead to changes in protein structure and function as well as in the interactions between proteins. These changes can disrupt cell function and contribute to the d...
Computers in biology and medicine
Jun 3, 2025
The exploration of anticancer drugs has aimed at more effective, adaptable, and less harmful treatments, with natural products pivotal in cancer research. In addition to experimental techniques for identifying anticancer drug candidates, computationa...
Nature reviews. Cancer
Jun 3, 2025
Development of acquired therapeutic resistance limits the efficacy of cancer treatments and accounts for therapeutic failure in most patients. How resistance arises, varies across cancer types and differs depending on therapeutic modalities is incomp...
Computers in biology and medicine
Jun 2, 2025
Surface-enhanced Raman spectroscopy (SERS) has emerged as a transformative analytical tool in disease diagnostics, offering unparalleled sensitivity and molecular fingerprinting capabilities. However, its clinical translation is hindered by the inher...
Molecular cancer
Jun 2, 2025
Cancer continues to be a significant international health issue, which demands the invention of new methods for early detection, precise diagnoses, and personalized treatments. Artificial intelligence (AI) has rapidly become a groundbreaking componen...
Journal for immunotherapy of cancer
May 30, 2025
BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform...
Molecular biology reports
May 30, 2025
Senescence is a pivotal cellular process, which also plays a major role in development, immune regulation, tissue repair, and aging, triggered by stressors such as telomere shortening, oncogene activation, and DNA damage. Characterized by distinct mo...
Oncology research
May 29, 2025
OBJECTIVES: Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening, targeted therapies, and immunotherapy, contributing to reduced mortality rates in cancer patients. Despit...
Scientific data
May 27, 2025
Pathology data, primarily consisting of slides and diagnostic reports, inherently contain knowledge that is pivotal for advancing data-driven biomedical research and clinical practice. However, the hidden and fragmented nature of this knowledge acros...
Theranostics
May 25, 2025
Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenes...