Cell communication and signaling : CCS
Oct 10, 2025
Early detection and personalized treatment strategies are essential for enhancing patient outcomes, as cancer continues to be a significant cause of mortality on a global basis. In clinical practice, the identification and validation of reliable biom...
Clinical oncology generates vast, unstructured data that often contain inconsistencies, missing information, and ambiguities, making it difficult to extract reliable insights for data-driven decision-making. General-purpose large language models (LLM...
Neutrophils are the most abundant granulocyte population and have important functions such as defense against pathogens. However, they show significant Heterogeneity and play more complex roles in tumors. The theory of two-tiered differentiation of n...
Spatial proteomics technologies have been pivotal in profiling tumor immune microenvironments at single-cell resolution, advancing our understanding of cancer biology, identifying key cell populations in solid tumors, and predicting treatment respons...
Cancer cells express high levels of programmed cell death-ligand 1 (PD-L1) to evade immune surveillance. PD-L1 interacts with PD-1 on T cells to make them non-functional. Thus, PD-L1 and PD-1 are pivotal targets in cancer immunotherapy. While anti-PD...
For most cancers, early diagnosis and intervention can significantly improve cure rates and patient survival. Consequently, achieving early and accurate cancer detection has always been a central focus in both medical practice and scientific research...
OBJECTIVE: Accurate cancer risk prediction is hindered by complex, multi-layered immune interactions, and traditional tissue biopsies are invasive and lack scalability for large-scale or repeated assessments. Peripheral blood offers a minimally invas...
BACKGROUND: Cancer is a complex disease influenced by numerous concurrent genetic factors that result in diverse tumor microenvironments (TMEs) across different cancer types. Large-scale genomic projects, such as The Cancer Genome Atlas, have undersc...
Cancer remains one of the most significant global health challenges, with its burden continuing to rise. The limitations of conventional anticancer therapies caused by the lack of tissue selectivity, demands urgent development of safer and more selec...
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