Compound selectivity prediction plays an important role in identifying potential compounds that bind to the target of interest with high affinity. However, there is still short of efficient and accurate computational approaches to analyze and predict...
We propose using a neural network approach in conjunction with digital holographic microscopy in order to rapidly determine relevant parameters such as the core and shell diameter of coated, non-absorbing spheres. We do so without requiring a time-co...
INTRODUCTION: The use of computational tools in the early stages of drug development has increased in recent decades. Machine learning (ML) approaches have been of special interest, since they can be applied in several steps of the drug discovery met...
Poor pharmacokinetic and toxicity profiles are major reasons for the low rate of advancing lead drug candidates into efficacy studies. The In-silico prediction of primary pharmacokinetic and toxicity properties in the drug discovery and development p...
Technology and health care : official journal of the European Society for Engineering and Medicine
Jan 1, 2016
Artificial neural networks have found applications in various areas of medical diagnosis. The capability of neural networks to learn medical data, mining useful and complex relationships that exist between attributes has earned it a major domain in d...
Water science and technology : a journal of the International Association on Water Pollution Research
Jan 1, 2016
Two new soft computing models, namely genetic programming (GP) and genetic artificial algorithm (GAA) neural network (a combination of modified genetic algorithm and artificial neural network methods) were developed in order to predict the percentage...
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Jan 1, 2016
INTRODUCTION: The decision to extract teeth for orthodontic treatment is important and difficult because it tends to be based on the practitioner's experiences. The purposes of this study were to construct an artificial intelligence expert system for...
BACKGROUND: Efficacy of melatonin in treating sleep disorders has been demonstrated in numerous studies. Being with short half-life, melatonin needs to be formulated in extended-release tablets to prevent the fast drop of its plasma concentration. Ho...
Yao xue xue bao = Acta pharmaceutica Sinica
Dec 1, 2015
A novel method was developed for the rapid determination of multi-indicators in corni fructus by means of near infrared (NIR) spectroscopy. Particle swarm optimization (PSO) based least squares support vector machine was investigated to increase the ...
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