Journal of molecular neuroscience : MN
Jul 16, 2025
DNA methylation plays a crucial role in the onset and progression of Alzheimer's disease (AD). Genome-wide methylation analysis of multi-tissue data can provide insights into the pathology and diagnostic biomarkers of AD. Computational tools were emp...
Advances in in vivo Ca imaging using miniature microscopes have enabled researchers to study single-neuron activity in freely moving animals. Tools such as Minian and CalmAn have been developed to convert Ca visual signals to numerical data, collecti...
Epilepsy is a common brain disease that causes different types of seizures, with an incidence rate of nearly 1%. N7-methylguanosine (m7G) is a prevalent RNA modification that has attracted significant attention in recent research. In this study, we i...
Activity recognition in live-cell imaging is labor-intensive and requires significant human effort. Existing automated analysis tools are largely limited in versatility. We present the Intelligent Vesicle Exocytosis Analysis (IVEA) platform, an Image...
Spiking neural networks drawing inspiration from biological constraints of the brain promise an energy-efficient paradigm for artificial intelligence. However, challenges exist in identifying guiding principles to train these networks in a robust fas...
Spiking neural networks (SNNs) are emerging as a promising evolution in neural network paradigms, offering an alternative to conventional convolutional neural networks (CNNs). One of the most effective methods for SNN development is the CNN-to-SNN co...
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
Critical network states and neural plasticity enable adaptive behavior in dynamic environments, supporting efficient information processing and experience-dependent learning. Synaptic-weight-based Hebbian plasticity and homeostatic synaptic scaling a...
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