Discontinuation of denosumab is associated with a rebound increase in osteoporotic fracture (OF) risk, and bisphosphonates (BPs) are commonly recommended as sequential therapy to mitigate this risk. However, their real-world effectiveness-and whether...
The main objective of osteoporosis management is to prevent osteoporotic fractures. Using machine learning methods, new risk variables can be identified to enhance the ability to identify women with osteoporosis who are at an increased risk of bone f...
UNLABELLED: This study used explainable AI to improve the Danish FREM model for predicting one-year risk of major osteoporotic fractures in over 2.4 million individuals aged ≥ 45. A DART boosting algorithm improved performance (AUC 0.77), with explai...
This study explores the use of radiomic features extracted from preoperative T2-weighted MRI and CT images, combined with machine learning models, to predict the risk of vertebral refracture after percutaneous kyphoplasty (PKP) in postmenopausal wome...
BACKGROUND: Osteoporotic vertebral fractures (OVFs) are common in older adults and often lead to disability if not properly diagnosed and classified. With the increased use of computed tomography (CT) imaging and the development of radiomics and deep...
BACKGROUND: Vertebral recompression after percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) may lead to recurrent pain, deformity, and neurological impairment, compromising prognosis and quality of life.
Osteoporosis is widespread with a high incidence rate, resulting in fragility fractures which are a major contributor to mortality among the elderly. Artificial intelligence (AI), in particular artificial neural networks, appears to be useful in mana...
International journal of medical informatics
Jun 3, 2025
BACKGROUND AND OBJECTIVE: To develop and validate a machine learning model based on stacking ensemble learning and feature selection strategies to predict vertebral refracture risk after percutaneous vertebroplasty.
Aging clinical and experimental research
May 26, 2025
BACKGROUND: The rising incidence of refractures and associated adverse outcomes among individuals with osteoporotic vertebral compression fractures has gained significant attention. Identifying refracture risk is crucial for implementing effective pr...
PURPOSE OF REVIEW: Genome-wide association studies (GWAS) have significantly advanced osteoporosis research by identifying genetic loci associated with bone mineral density (BMD) and fracture risk. However, disparities persist due to the underreprese...
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