AIMC Topic: Pancreatic Neoplasms

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Automated Resectability Classification of Pancreatic Cancer CT Reports with Privacy-Preserving Open-Weight Large Language Models: A Multicenter Study.

Journal of medical systems
 To evaluate the effectiveness of open-weight large language models (LLMs) in extracting key radiological features and determining National Comprehensive Cancer Network (NCCN) resectability status from free-text radiology reports for pancreatic ducta...

Exploring the survival benefits of surgical treatment for pancreatic adenocarcinoma using the DeepSurv neural network model.

Computer assisted surgery (Abingdon, England)
To develop a DeepSurv model for predicting survival in pancreatic adenocarcinoma patients, evaluating the benefit of surgical versus non-surgical treatment across different stages, including stage IV subcategories. Clinical data were extracted from t...

Synthetic data generation method improves risk prediction model for early tumor recurrence after surgery in patients with pancreatic cancer.

Scientific reports
Pancreatic cancer is aggressive with high recurrence rates, necessitating accurate prediction models for effective treatment planning, particularly for neoadjuvant chemotherapy or upfront surgery. This study explores the use of variational autoencode...

Development and validation of a diagnostic prediction model for pancreatic ductal adenocarcinoma: VAPOR 1, protocol for a prospective multicentre case-control study.

BMJ open
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) continues to have extremely poor patient outcomes, unlike other cancer types which have seen significant improvements in their treatments and survival. A major contributing factor is that PDAC is ...

Serum peptide biomarkers by MALDI-TOF MS coupled with machine learning for diagnosis and classification of hepato-pancreato-biliary cancers.

Scientific reports
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...

Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer.

eLife
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...

Effectiveness of Radiomics-Based Machine Learning Models in Differentiating Pancreatitis and Pancreatic Ductal Adenocarcinoma: Systematic Review and Meta-Analysis.

Journal of medical Internet research
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP) share similar clinical, laboratory, and imaging features, making accurate diagnosis challenging. Nevertheless, PDAC is highly malignant with a poor prognosis, whe...

SPP1 + macrophages facilitate pancreatic cancer progression via ITGB6-mediated interactions: evidence from integrated multi-omics analysis and experimental validation.

Immunologic research
Basement membranes (BMs) and tumor-associated macrophages (TAMs) are crucial stromal components in pancreatic cancer (PC), critically influencing disease progression. Bulk and single-cell RNA-seq (scRNA-seq) data were acquired from publicly available...