BACKGROUND: Glaucoma is a progressive neurodegenerative disease of the optic nerve and one of the leading causes of irreversible blindness worldwide. Small RNAs (including miRNAs) play an important role in the pathogenesis of the disease. Despite ext...
PURPOSE: Proliferative Diabetic Retinopathy (PDR) is a severe complication of diabetes characterized by neovascularization and retinal detachment, leading to significant vision loss. This study investigates the predictive power of hematological and i...
Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this problem by integ...
PURPOSE: Various immune mediators have crucial roles in the pathogenesis of intraocular diseases. Machine learning can be used to automatically select and weigh various predictors to develop models maximizing predictive power. However, these techniqu...
The purpose of this study is to examine if aqueous autotaxin (ATX) and TGF-β levels could be used for differentiating glaucoma subtypes. This prospective observational study was performed using aqueous humor samples obtained from 281 consecutive pati...
Probing the viscosity of human aqueous humor is crucial for optimizing micro-tube shunts in glaucoma treatment. However, conventional viscometers are not suitable for aqueous humor due to the limited sample volume-only tens of microliters-that can be...
Retinal OCT biomarker analysis by artificial intelligence (AI) has not previously been integrated with proteomics. Here, we combined the two techniques to elucidate novel molecular mechanisms in central retinal vein occlusion (CRVO). Proteomic data o...
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