AIMC Topic: Plasmids
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Synthesis Success Calculator: Predicting the Rapid Synthesis of DNA Fragments with Machine Learning.
ACS synthetic biology
Jun 30, 2020
The synthesis and assembly of long DNA fragments has greatly accelerated synthetic biology and biotechnology research. However, long turnaround times or synthesis failures create unpredictable bottlenecks in the design-build-test-learn cycle. We deve...
Construction of arming Yarrowia lipolytica surface-displaying soybean seed coat peroxidase for use as whole-cell biocatalyst.
Enzyme and microbial technology
Dec 20, 2019
Whole-cell biocatalysts could be used in wide-ranging applications. In this study, a new kind of whole-cell biocatalyst was successfully constructed by genetically immobilizing soybean seed coat peroxidase (SBP) on the cell surface of Yarrowia lipoly...
Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.
Poultry science
Dec 12, 2019
Plasmid-mediated quinolone resistance (PMQR) genes located on conjugative plasmids can be transferred to other bacteria in the absence of antimicrobial selective pressure. To elucidate the prevalence of resistance, including PMQR in an egg-producing ...
Emergence of mcr-1 mediated colistin resistant Escherichia coli from a hospitalized patient in Bangladesh.
Journal of infection in developing countries
Aug 31, 2019
INTRODUCTION: The emergence of plasmid mediated mcr in bacteria has become global public health threat. Herein, we report a mcr-1 positive E. coli in normal human flora from a patient admitted in Dhaka Medical College Hospital (DMCH).
Deep learning to predict the lab-of-origin of engineered DNA.
Nature communications
Aug 7, 2018
Genetic engineering projects are rapidly growing in scale and complexity, driven by new tools to design and construct DNA. There is increasing concern that widened access to these technologies could lead to attempts to construct cells for malicious i...
Baicalin inhibits Escherichia coli isolates in bovine mastitic milk and reduces antimicrobial resistance.
Journal of dairy science
Dec 28, 2017
In this study, we aimed to evaluate the inhibitory effect of baicalin on Escherichia coli in vitro and the effects of baicalin treatment on antimicrobial resistance of the E. coli isolates. Through isolation, purification, and identification, a total...
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.
Journal of pharmaceutical sciences
Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
Effects of mutations on the structure and function of silkworm type 1 acetylcholinesterase.
Pesticide biochemistry and physiology
Nov 10, 2015
AChE is the target of organophosphate (OP) and carbamate (CB) pesticides, and mutations in the gene can significantly reduce insects' sensitivity to these pesticides. Bombyx mori is highly sensitive to pesticides. To investigate the effects of mutati...
MOSTPLAS: a self-correction multi-label learning model for plasmid host range prediction.
Bioinformatics (Oxford, England)
Mar 4, 2025
MOTIVATION: Plasmids play an essential role in horizontal gene transfer, aiding their host bacteria in acquiring beneficial traits like antibiotic and metal resistance. There exist some plasmids that can transfer, replicate, or persist in multiple or...
Predicting the bacterial host range of plasmid genomes using the language model-based one-class support vector machine algorithm.
Microbial genomics
Feb 1, 2025
The prediction of the plasmid host range is crucial for investigating the dissemination of plasmids and the transfer of resistance and virulence genes mediated by plasmids. Several machine learning-based tools have been developed to predict plasmid h...
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