Herein, a novel tri-functional Mn-doped covalent organic polymer nanozyme (Mn-COP) with peroxidase-like, oxidase-like, and laccase-like activities was synthesized. The strong reducing power of flavonoids inhibited the tri-enzymes-like activity from M...
Lumbar spinal stenosis involves pathological narrowing of the spinal canal, whereas disc degeneration refers to the progressive deterioration of intervertebral disc structure and function. Interspinous process devices (ISPs) are commonly used to mana...
Neural cells reside in a three-dimensional (3D) microenvironment where the structure of the nerve circuitry is shaped by the morphology and stiffness of the surrounding extracellular matrix. In this environment, regular exposure to varying mechanical...
Journal of chemical information and modeling
Sep 9, 2025
The development of low-cost, high-performance materials with enhanced transparency in the long-wavelength infrared (LWIR) region (800-1250 cm/8-12.5 μm) is essential for advancing thermal imaging and sensing technologies. Traditional LWIR optics rely...
Salmonella typhimurium (S. typhimurium) A dual-mode colorimetric/photothermal immunochromatographic strip (ICS) employing hollow polydopamine nanoparticles (h-PDA) is reported for the ultrasensitive detection of Salmonella typhimurium (S. typhimurium...
3D printing has brought significant changes to manufacturing sectors, making it possible to produce intricate, multi-layered designs with greater ease. This study focuses on optimizing the compressive strength (CS) of functionally graded multi-materi...
To address the challenges in detecting chloramphenicol (CAP) in complex food matrices, this study developed a magnetic solid-phase microextraction coupled with a high-performance liquid chromatography (MSPME-HPLC) system that integrates machine learn...
International journal of pharmaceutics
Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
There is an urgent need for rapid, affordable diagnostics for Alzheimer's disease (AD), particularly those that can detect phosphorylated Tau 181 (p-tau181)─a key biomarker─directly in plasma. We present a scalable, label-free electrochemical biosens...
International journal of biological macromolecules
Jul 28, 2025
Enzyme-triggered polymersomes have emerged as a transformative platform in liquid biopsy and cancer diagnostics, enabling high-accuracy biomarker detection through precise enzymatic responsiveness. This review comprehensively examines the rational de...
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