AIMC Topic: Precision Medicine

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Gut microbiota as a regulator of vaccine efficacy: implications for personalized vaccination.

Gut microbes
Vaccines are one of the most significant achievements in global health, as they have substantially reduced morbidity and mortality from infectious diseases. However, the vaccine efficacy varies markedly across different populations, particularly amon...

The Road to Precision Nanomedicine: An Insight on Drug Repurposing and Advances in Nanoformulations for Treatment of Cancer.

AAPS PharmSciTech
Cancer remains one of the most significant global health challenges, with its burden continuing to rise. The limitations of conventional anticancer therapies caused by the lack of tissue selectivity, demands urgent development of safer and more selec...

A Trust-Aware Architecture for Personalized Digital Health: Integrating Blueprint Personas and Ontology-Based Reasoning.

Journal of medical systems
This paper presents a trust-aware architecture for personalized digital health that combines user modeling, symbolic reasoning, and adaptive trust mechanisms. The proposed system uses Blueprint Personas to capture detailed patient profiles, including...

Computational pathology in precision oncology: Evolution from task-specific models to foundation models.

Chinese medical journal
With the rapid development of artificial intelligence, computational pathology has been seamlessly integrated into the entire clinical workflow, which encompasses diagnosis, treatment, prognosis, and biomarker discovery. This integration has signific...

Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile.

BMJ open
PURPOSE: Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substant...

From reactive to proactive: Continuous protein monitoring for preventive health care.

Science (New York, N.Y.)
Continuous biomarker monitoring is revolutionizing chronic disease management, with glucose monitoring for diabetes as the primary example. Given the success of this approach, a transition to continuous protein monitoring (CPM, a real-time, implantab...

Artificial intelligence in healthcare and medicine: clinical applications, therapeutic advances, and future perspectives.

European journal of medical research
Healthcare systems worldwide face growing challenges, including rising costs, workforce shortages, and disparities in access and quality, particularly in low- and middle-income countries. Artificial intelligence (AI) has emerged as a transformative t...

Harnessing AI for precision medicine and its applications in genomics, systems pharmacology, and drug discovery.

European journal of pharmacology
Artificial intelligence and machine learning are revolutionizing pharmaceutical research by enabling the rapid analysis of complex datasets and automating critical tasks throughout the drug-development process. In this review, we surveyed how artific...

Cutting-edge nanobiosensors: Revolutionizing cancer diagnosis and enabling precision medicine.

Clinica chimica acta; international journal of clinical chemistry
Integrating nanotechnology and artificial intelligence (AI) revolutionizes cancer diagnostics, propelling precision medicine into a transformative era. This review examines state-of-the-art nanobiosensors capable of detecting critical biomarkers-circ...

Organoids as predictive platforms: advancing disease modeling, therapeutic innovation, and drug delivery systems.

Journal of controlled release : official journal of the Controlled Release Society
As three-dimensional (3D), physiologically relevant models, organoids are rapidly becoming revolutionary platforms in biomedical research. With their ability to recapitulate tissue architecture, disease heterogeneity, and patient-specific therapeutic...