AIMC Topic: Protein Interaction Maps

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MAGPIE: A Machine Learning Approach to Decipher Protein-Protein Interactions in Human Plasma.

Journal of proteome research Jan 7, 2025
Immunoprecipitation coupled to tandem mass spectrometry (IP-MS/MS) methods are often used to identify protein-protein interactions (PPIs). While these approaches are prone to false positive identifications through contamination and antibody nonspecif...
Protein Interaction Mapping Blood Proteins Tandem Mass Spectrometry Immunoprecipitation Humans Machine Learning Algorithms Protein Interaction Maps Proteomics
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Deciphering Necroptosis-Associated Molecular Subtypes in Acute Ischemic Stroke Through Bioinformatics and Machine Learning Analysis.

Journal of molecular neuroscience : MN Jan 2, 2025
Acute ischemic stroke (AIS) is a severe disorder characterized by complex pathophysiological processes, which can lead to disability and death. This study aimed to determine necroptosis-associated genes in acute ischemic stroke (AIS) and to investiga...
Humans Machine Learning Computational Biology Necroptosis Ischemic Stroke Transcriptome Protein Interaction Maps Gene Regulatory Networks
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Analysis of diagnostic genes and molecular mechanisms of Crohn's disease and colon cancer based on machine learning algorithms.

Scientific reports Dec 30, 2024
Crohn's disease (CD) is a chronic inflammatory bowel condition, and colon adenocarcinoma (COAD), as one of the most prevalent malignant tumors of the digestive tract, has been indicated by research to have a close association with CD. This study empl...
Matrix Metalloproteinase 3 Databases, Genetic Crohn Disease Algorithms Colonic Neoplasms Biomarkers, Tumor Gene Expression Profiling Humans Computational Biology Machine Learning ROC Curve Gene Expression Regulation, Neoplastic Protein Interaction Maps Adenocarcinoma Gene Regulatory Networks
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Interpretable machine learning-driven biomarker identification and validation for Alzheimer's disease.

Scientific reports Dec 28, 2024
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by limited effective treatments, underscoring the critical need for early detection and diagnosis to improve intervention outcomes. This study integrates various bioinformatics me...
Biomarkers Gene Expression Profiling Transcriptome Protein Interaction Maps Gene Regulatory Networks Computational Biology Alzheimer Disease Humans Machine Learning
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Analysis of the basement membrane-related genes ITGA7 and its regulatory role in periodontitis via machine learning: a retrospective study.

BMC oral health Dec 24, 2024
BACKGROUND: Periodontitis is among the most prevalent inflammatory conditions and greatly impacts oral health. This study aimed to elucidate the role of basement membrane-related genes in the pathogenesis and diagnosis of periodontitis.
MicroRNAs RNA, Long Noncoding Periodontitis Retrospective Studies Humans Antigens, CD Protein Interaction Maps Machine Learning Integrin alpha Chains RNA, Messenger Basement Membrane
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Identification and validation of susceptibility modules and hub genes in polyarticular juvenile idiopathic arthritis using WGCNA and machine learning.

Autoimmunity Dec 19, 2024
BACKGROUND: Juvenile idiopathic arthritis (JIA), superseding juvenile rheumatoid arthritis (JRA), is a chronic autoimmune disease affecting children and characterized by various types of childhood arthritis. JIA manifests clinically with joint inflam...
Arthritis, Juvenile Gene Ontology Child Protein Interaction Maps Gene Regulatory Networks Genetic Predisposition to Disease Prognosis Computational Biology Humans Gene Expression Profiling Databases, Genetic Machine Learning Transcriptome Biomarkers
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Identification and validation of the diagnostic biomarker MFAP5 for CAVD with type 2 diabetes by bioinformatics analysis.

Frontiers in immunology Dec 19, 2024
INTRODUCTION: Calcific aortic valve disease (CAVD) is increasingly prevalent among the aging population, and there is a notable lack of drug therapies. Consequently, identifying novel drug targets will be of utmost importance. Given that type 2 diabe...
Aortic Valve Protein Interaction Maps Gene Regulatory Networks Computational Biology Gene Expression Profiling Databases, Genetic Humans Transcriptome Calcinosis Machine Learning Diabetes Mellitus, Type 2 Aortic Valve Stenosis Biomarkers
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Deep representation learning of protein-protein interaction networks for enhanced pattern discovery.

Science advances Dec 18, 2024
Protein-protein interaction (PPI) networks, where nodes represent proteins and edges depict myriad interactions among them, are fundamental to understanding the dynamics within biological systems. Despite their pivotal role in modern biology, reliabl...
Humans Algorithms Deep Learning Protein Interaction Maps Computational Biology Protein Interaction Mapping
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Developing the new diagnostic model by integrating bioinformatics and machine learning for osteoarthritis.

Journal of orthopaedic surgery and research Dec 18, 2024
BACKGROUND: Osteoarthritis (OA) is a common cause of disability among the elderly, profoundly affecting quality of life. This study aims to leverage bioinformatics and machine learning to develop an artificial neural network (ANN) model for diagnosin...
Neural Networks, Computer Machine Learning Gene Expression Profiling Humans Protein Interaction Maps Computational Biology Osteoarthritis
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Bringing neural networks to life.

Science (New York, N.Y.) Dec 12, 2024
A synthetic protein-based winner-take-all neural network controls cell fate decisions.
Synthetic Biology Humans Neural Networks, Computer Protein Interaction Maps
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