AIMC Topic: Quantitative Trait, Heritable

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Multiple Trait Covariance Association Test Identifies Gene Ontology Categories Associated with Chill Coma Recovery Time in Drosophila melanogaster.

Scientific reports
The genomic best linear unbiased prediction (GBLUP) model has proven to be useful for prediction of complex traits as well as estimation of population genetic parameters. Improved inference and prediction accuracy of GBLUP may be achieved by identify...

Semi-supervised learning for genomic prediction of novel traits with small reference populations: an application to residual feed intake in dairy cattle.

Genetics, selection, evolution : GSE
BACKGROUND: Genomic prediction for novel traits, which can be costly and labor-intensive to measure, is often hampered by low accuracy due to the limited size of the reference population. As an option to improve prediction accuracy, we introduced a s...

Application of neural networks with back-propagation to genome-enabled prediction of complex traits in Holstein-Friesian and German Fleckvieh cattle.

Genetics, selection, evolution : GSE
BACKGROUND: Recently, artificial neural networks (ANN) have been proposed as promising machines for marker-based genomic predictions of complex traits in animal and plant breeding. ANN are universal approximators of complex functions, that can captur...

Brief Survey on Machine Learning in Epistasis.

Methods in molecular biology (Clifton, N.J.)
In biology, the term "epistasis" indicates the effect of the interaction of a gene with another gene. A gene can interact with an independently sorted gene, located far away on the chromosome or on an entirely different chromosome, and this interacti...

DeepPod: a convolutional neural network based quantification of fruit number in Arabidopsis.

GigaScience
BACKGROUND: High-throughput phenotyping based on non-destructive imaging has great potential in plant biology and breeding programs. However, efficient feature extraction and quantification from image data remains a bottleneck that needs to be addres...

Discovery of phenotypic networks from genotypic association studies with application to obesity.

International journal of data mining and bioinformatics
Genome-wide Association Studies (GWAS) have resulted in many discovered risk variants for several obesity-related traits. However, before clinical relevance of these discoveries can be achieved, molecular or physiological mechanisms of these risk var...

Epistasis analysis using multifactor dimensionality reduction.

Methods in molecular biology (Clifton, N.J.)
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the ke...