AIMC Topic: Rats

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Virtual Screening of Nrf2 Dietary-Derived Agonists and Safety by a New Deep-Learning Model and Verified and .

Journal of agricultural and food chemistry
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an essential regulatory target of antioxidants, but the lack of Nrf2 active site information has hindered discovery of new Nrf2 agonists from food-derived compounds by large-scale virtual screenin...

FPGA-Based In-Vivo Calcium Image Decoding for Closed-Loop Feedback Applications.

IEEE transactions on biomedical circuits and systems
Miniaturized calcium imaging is an emerging neural recording technique that has been widely used for monitoring neural activity on a large scale at a specific brain region of rats or mice. Most existing calcium-image analysis pipelines operate offlin...

A hybrid approach to full-scale reconstruction of renal arterial network.

Scientific reports
The renal vasculature, acting as a resource distribution network, plays an important role in both the physiology and pathophysiology of the kidney. However, no imaging techniques allow an assessment of the structure and function of the renal vasculat...

Machine learning-assisted data filtering and QSAR models for prediction of chemical acute toxicity on rat and mouse.

Journal of hazardous materials
Machine learning (ML) methods provide a new opportunity to build quantitative structure-activity relationship (QSAR) models for predicting chemicals' toxicity based on large toxicity data sets, but they are limited in insufficient model robustness du...

Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models.

International journal of neural systems
Electrical stimulation of the peripheral nervous system is a promising therapeutic option for several conditions; however, its effects on tissue and the safety of the stimulation remain poorly understood. In order to devise stimulation protocols that...

Decoding behavior from global cerebrovascular activity using neural networks.

Scientific reports
Functional Ultrasound (fUS) provides spatial and temporal frames of the vascular activity in the brain with high resolution and sensitivity in behaving animals. The large amount of resulting data is underused at present due to the lack of appropriate...

Biphasic burst and sustained transdermal delivery in vivo using an AI-optimized 3D-printed MN patch.

International journal of pharmaceutics
The objective of the present study was to fabricate microneedles for delivering lipophilic active ingredients (APIs) using digital light processing (DLP) printing technology and quality by design (QbD) supplemented by artificial intelligence (AI) alg...

Recurrent networks endowed with structural priors explain suboptimal animal behavior.

Current biology : CB
The strategies found by animals facing a new task are determined both by individual experience and by structural priors evolved to leverage the statistics of natural environments. Rats quickly learn to capitalize on the trial sequence correlations of...

AI-based MRI auto-segmentation of brain tumor in rodents, a multicenter study.

Acta neuropathologica communications
Automatic segmentation of rodent brain tumor on magnetic resonance imaging (MRI) may facilitate biomedical research. The current study aims to prove the feasibility for automatic segmentation by artificial intelligence (AI), and practicability of AI-...

An end-end deep learning framework for lesion segmentation on multi-contrast MR images-an exploratory study in a rat model of traumatic brain injury.

Medical & biological engineering & computing
Traumatic brain injury (TBI) engenders traumatic necrosis and penumbra-areas of secondary neural injury which are crucial targets for therapeutic interventions. Segmenting manually areas of ongoing changes like necrosis, edema, hematoma, and inflamma...