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Integration of velocity-dependent spatio-temporal structure of place cell activation during navigation in a reservoir model of prefrontal cortex.

Biological cybernetics
Sequential behavior unfolds both in space and in time. The same spatial trajectory can be realized in different manners in the same overall time by changing instantaneous speeds. The current research investigates how speed profiles might be given beh...

Development of non-bias phenotypic drug screening for cardiomyocyte hypertrophy by image segmentation using deep learning.

Biochemical and biophysical research communications
The number of patients with heart failure and related deaths is rapidly increasing worldwide, making it a major problem. Cardiac hypertrophy is a crucial preliminary step in heart failure, but its treatment has not yet been fully successful. In this ...

Deep Learning-Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure.

Toxicologic pathology
As regulators of homeostasis, astrocytes undergo morphological changes after injury to limit the insult in central nervous system (CNS). Trimethyltin (TMT) is a known neurotoxicant that induces reactive astrogliosis in rat CNS. To evaluate the degree...

In Silico Prediction of Human and Rat Liver Microsomal Stability via Machine Learning Methods.

Chemical research in toxicology
Liver microsomal stability is an important property considered for the screening of drug candidates in the early stage of drug development. Determination of hepatic metabolic stability can be performed by an in vitro assay, but it requires quite a fe...

Danshao Shugan Granule therapy for non-alcoholic fatty liver disease.

Lipids in health and disease
BACKGROUND: Danshao Shugan Granules (DSSG), a traditional Chinese medicine (TCM), is given to protect the liver. The objective is to evaluate the mechanisms of the effects of DSSG on non-alcoholic fatty liver disease (NAFLD).

RAt-CapsNet: A Deep Learning Network Utilizing Attention and Regional Information for Abnormality Detection in Wireless Capsule Endoscopy.

IEEE journal of translational engineering in health and medicine
: The emergence of wireless capsule endoscopy (WCE) has presented a viable non-invasive mean of identifying gastrointestinal diseases in the field of clinical gastroenterology. However, to overcome its extended time of manual inspection, a computer a...

Toxicity, genotoxicity, and carcinogenicity of 2-methylfuran in a 90-day comprehensive toxicity study in gpt delta rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
2-Methylfuran (2-MF) exists naturally in foods and is used as a flavoring agent. Furan, the core structure of 2-MF, possesses hepatocarcinogenicity in rodents. Accumulation of toxicological information on furan derivatives is needed to elucidate thei...

Influences of Edaravone on Necroptosis-Related Proteins and Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion Injury.

Cellular and molecular biology (Noisy-le-Grand, France)
The study aimed to investigate the influences of edaravone on necroptosis-related proteins and oxidative stress in rats with lower extremity ischemia/reperfusion (I/R) injury. The normal group (n=10), model group (lower extremity I/R injury model, n=...

Intermittent fasting-induced biomolecular modifications in rat tissues detected by ATR-FTIR spectroscopy and machine learning algorithms.

Analytical biochemistry
This study aimed to reveal the intermittent fasting-induced alterations in biomolecules of the liver, ileum, and colon tissues of rats using Support Vector Machine (SVM) and Linear Discriminant Analysis (LDA) algorithms developed on infrared spectroc...

Changes of Mass Spectra Patterns on a Brain Tissue Section Revealed by Deep Learning with Imaging Mass Spectrometry Data.

Journal of the American Society for Mass Spectrometry
The characteristic patterns of mass spectra in imaging mass spectrometry (IMS) strongly reflect the tissue environment. However, the boundaries formed where different tissue environments collide have not been visually assessed. In this study, IMS and...